SUFU 2008 Winter Meeting - Biochemical Basis For SUI/Pelvic Organ Prolapse

Main Category: Urology / Nephrology
Also Included In: Conferences
Article Date: 16 Mar 2008 - 0:00 PDT

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UroToday.com - Pelvic organ prolapse (POP) and stress urinary incontinence (SUI), both of which are related to pelvic floor weakness, are prevalent amongst women in the United States. Dr. Gopal Badlani presented an intriguing lecture about collagen, elastin, and the effects of estrogen on the tissues of women with SUI compared with women who do not have SUI.

In short, increased breakdown of collagen and elastin via escalated collagenolytic and elastase activity has been found in both the skin and the pubocervical fascia of women with SUI. Additionally, fibroblasts from women with and without SUI appear to respond differently to estrogen and elastolytic activity in the fibroblasts of women with SUI is significantly increased compared with those without SUI.

Presented by: Gopal H. Badlani, MD at the Society for Urodynamics and Female Urology (SUFU) 2008 Winter Meeting - February 28 - March 2, 2008 Miami, Florida, USA

Reported by Kathleen Kobashi, MD - Head, Section of Urology and Renal Transplantation, Co-Director of The Virginia Mason Medical Center Continence Center - Seattle, WA USA and Clinical Associate Professor of Urology at the University of Washington - Seattle, WA USA

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