Search is Powered by Google
Follow us on:
Follow our health news on Twitter
Follow Our News on Facebook
Personalization
login | register
Biology / Biochemistry News

Gentronix Launches New Genotoxic Metabolite Detection Assay GreenScreen HC Available From Gentronix Limited

Main Category: Biology / Biochemistry
Article Date: 17 Mar 2008 - 0:00 PDT

email icon email to a friend   printer icon printer friendly   write icon view / write opinions   rate icon rate article
Current Article Ratings:

Patient / Public:not yet rated

Health Professional:not yet rated

Article Opinions: 0 posts

Now available with an S9 protocol to detect genotoxic metabolites, GreenScreen HC from Gentronix is a human cell-based genotoxicity screening assay used in drug discovery programmes during lead compound optimisation and candidate selection.

Potential pharmaceutical compounds which only present a genotoxicity hazard after metabolism, usually by the liver, are known as pro-genotoxins. The utility of GreenScreen HC has now been extended to detect pro genotoxins as well as all common mechanistic classes of genotoxin including mutagens, clastogens, aneugens, as well as both topoisomerase and polymerase inhibitors.

Using a standardized 96-well microplate format, the test compound and patented Green Fluorescent Protein (GFP) reporter cells are combined with 1% S9 for a 3 hour exposure period. After exposure, cells are washed to remove the S9 and test compound and then allowed a further 45 hour recovery incubation. Cell viability and GFP fluorescence data are assessed using flow cytometry and simple software generates quantitative results and a graphical output.

Minimal investment in early genotoxicity screening delivers major time savings, avoids unnecessary animal testing and prevents costly late stage failures of lead drug compounds through early detection of genotoxic potential. Combining exceptional levels of specificity and sensitivity, GreenScreen HC also correctly identifies non-carcinogenic compounds known to give misleading positive results in other in vitro genotoxicity assays.

Gentronix
http://www.gentronix.co.uk




Personalized Homepage Weekly Newsletters Daily News Alerts
Hemophilia Opioid Induced Constipation Pneumococcal Disease ADHD Anxiety Asthma Atrial Fibrillation Autism Cancer Diabetes Lung Cancer Lupus Medicare / Medicaid Obesity and BMI Pancreatic Cancer Stem Cells All 'What Is...' Articles

Ophthalmology Urology
About Us News Licensing Free Website Feeds Free Tools & Content Tell a Friend Accessibility Help / FAQ Article Submission Links Contact Us

add medical news today to your facebook
medical news gadget

Please fill in our survey

Swine Flu Image

Swine Flu Updates

- Latest Swine Flu News
- What is Swine Flu?
- Map Of H1N1 Outbreaks
- Swine Flu - Top 20 FAQ
- Daily Email News Alerts
Stick with Medical News Today for the latest news updates on swine flu.


These are the most read articles from this news category for the last 6 months:
Top Article Star
What Are Bed Bugs? How To Kill Bed Bugs
20 Jul 2009
Bed bugs, known scientifically as Cimex lectularius (Cimicidae) are small wingless insects that feed by hematophagy - exclusively on the blood of warm blooded-animals. As we are warm-blooded animals we are ideal hosts for them...


When Clutter Takes Over Your Life
When Clutter Takes Over Your Life

Clutter had taken over Cora's life. Working with a professional organizer and finding out what's beneath the clutter is helping her get her life back.

more videos are available in our health videos section.