Dyspareunia Response In Patients With Interstitial Cystitis Treated With Intravesical Lidocaine, Bicarbonate And Heparin

Main Category: Urology / Nephrology
Also Included In: Clinical Trials / Drug Trials
Article Date: 31 Mar 2008 - 0:00 PDT

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UroToday.com - Pilot Study Suggests Intravesical Treatment Effective for Dyspareunia Associated with BPS/IC.

Dyspareunia, recurrent or persistent genital pain associated with sexual intercourse, is commonly associated with BPS/IC. An inexpensive intravesical cocktail that many patients can easily self-administer has shown benefit for pain, urgency, and frequency of BPS/IC1. It consists of 8ml of 2% lidocaine, 4ml of 8.4% sodium bicarbonate, and 20,000 units of heparin (10,000 units per cc). Welk and Teichman looked at the effect of this treatment, administered 3 times weekly for 3 weeks, on the symptom of dyspareunia in a small group of patients.

Twenty-three patients were included in the study. All patients had dyspareunia at the outset, and 57% reported resolution of dyspareunia after treatment. Eleven of 13 patients who had bladder tenderness only were successful in terms of dyspareunia, while only 2 of 7 with multiple tender locations reported success. The study was brief, and it is unknown whether continued instillations are necessary to maintain success, or if patients develop tachyphylaxis to the treatments over time.

The authors conclude that these encouraging results warrant a larger, randomized, placebo-controlled trial.

Blayne K. Welk , Joel M.H. Teichman

Urology. 2008 Jan;71(1):67-70
doi:10.1016/j.urology.2007.09.067

Reported by UroToday.com Contributing Editor Philip M. Hanno, MD, MPH

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