Growing Use Of Cell-Based Assays Reported In Genetic Engineering & Biotechnology News

Main Category: Medical Devices
Also Included In: Pharma Industry / Biotech Industry;  Biology / Biochemistry
Article Date: 17 Apr 2008 - 5:00 PDT

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Biotech and pharma companies are increasingly relying on cell-based assays in early drug discovery work, reports Genetic Engineering & Biotechnology News (GEN). The technique can provide a quick and lower cost means of testing drug candidates for toxic effects, according to an article in GEN (http://www.genengnews.com/articles/chitem.aspx?aid=2437).

"Better screening technologies, noninvasive monitoring, and more automation are driving the trend toward adoption of this technology," notes John Sterling, Editor-in-Chief of GEN. "Some estimates project that the market for cell-based assays will more than double over the next six or seven years to over $230 million. This is definitely a methodology that should draw the interest of new drug developers."

More than 50% of currently marketed drugs target GPCRs, which impact a wide range of cellular processes. Multispan is looking to exploit this area and is collaborating with Promega and Molecular Devices to develop an array of applications for its GPCR cell-based assays.

Another field of much R&D interest involves protein-protein interactions. DiscoveRx created a new family of cell-based assays for the detection of protein-protein interactions using an enzyme fragment complementation assay. This system uses an enzyme acceptor, an inactive alpha-galactosidase enzyme that binds to its enzyme donor forming an active enzyme that will hydrolyze a substrate and provide a signal.

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Article adapted by Medical News Today from original press release.
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Other companies covered in the GEN article include Merck Research Laboratories, Sophion, Nanion, Novo Nordisk, ACEA Biosciences, and AstraZeneca.

Genetic Engineering and Biotechnology News (http://www.genengnews.com/), which is published 21 times a year by Mary Ann Liebert, Inc., is the most widely read biotechnology news magazine worldwide. It includes articles on Drug Discovery, Bioprocessing, OMICS, Biobusiness, and Clinical Research and Diagnostics.

Source: Vicki Cohn
Mary Ann Liebert, Inc./Genetic Engineering News