Kidney Cancer And The Risk For Chronic Kidney Disease: Matched-Paired Comparison With Living Donors

Main Category: Urology / Nephrology
Also Included In: Cancer / Oncology
Article Date: 09 Jun 2008 - 0:00 PST

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ORLANDO, FL (UroToday.com) - Dr Koenig from the Cleveland Clinic presented some important data regarding the risk of chronic renal disease in patients diagnosed with kidney cancer.

Living kidney donors tolerate nephrectomy without long-term sequelae and this is often extrapolated to patients with renal tumors. This study evaluated data from 947 patients undergoing surgery for clinically-localized kidney cancer and was compared to 434 patients who had undergone a living donor nephrectomy. Matched-paired analysis (n=228 for each group) correcting for age, sex, and ethnicity was performed to evaluate general medical condition, comorbidities, and baseline renal function.

Kidney cancer patients presented with higher ASA and ECOG scores along with a higher incidence of HTN, DM, CAD and nephrolithiasis. Furthermore, their serum creatinine was 24% higher and MDRD was 30% lower compared to the living donor group. On multivariate analysis, age, sex, and kidney cancer were identified as independent predictors of an eGFR <60 mL/min/1.73m2.

The conclusion is that patients who present with renal cancer generally have a poorer baseline renal function and a greater risk factors for developing CRD compared to kidney donors, underscoring the importance of nephron-sparing surgery in appropriately selected patients.

Presented by Phillipe Koenig, Inderbir Gill, Kazumi Kamoi, Monish Aron, Georges-Pascal Haber, Ayesha Singh, Christopher Weight, Mihir Desai, Jihad Kaouk, David Goldfarb, Emilio Poggio at the Annual Meeting of the American Urological Association (AUA) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA.

Reported by UroToday.com Contributing Editor Geoff Box, MD

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