The High-Resolution Genomic Profiling Using Whole-Genome Single Nucleotide Polymorphism Genotyping In Clear Cell Renal Cell Carcinoma

Main Category: Urology / Nephrology
Also Included In: Cancer / Oncology;  Genetics
Article Date: 11 Jun 2008 - 5:00 PDT

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ORLANDO, FL (UroToday.com) - A chip with some 370,00 single nucleotide polymorphisms (SNP) markers was used to evaluate the DNA fingerprint of clear cell renal cell carcinoma (ccRCC).

Extremely high resolution DNA changes were detected. Most changes were seen on the short arm of the chromosome 3, confirming the role of the VHL gene in pathogenesis of ccRCC.

Application of this technique to other RCC subtypes should prove informative.

Presented by Akira Yokomizo, MD, Ken Yamamoto, MD, Yasuhiro Tada, MD, Seiji Naito, MD, at the Annual Meeting of the American Urological Association (AUA) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA.

Reported by UroToday.com Contributing Editor Alexander Kutikov, MD

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