Animal Foods, Protein, Calcium And Prostate Cancer Risk: The European Prospective Investigation Into Cancer And Nutrition

Main Category: Prostate / Prostate Cancer
Also Included In: Urology / Nephrology;  Nutrition / Diet;  Clinical Trials / Drug Trials
Article Date: 13 Jun 2008 - 3:00 PDT

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UroToday.com - Dr. Allen and a large group of European investigators report their data evaluating intake of protein and the risk of developing prostate cancer (CaP). In the online version of the British Journal of Cancer, they cite other studies that implicate a possible link. Their study used the European Prospective Investigation into Cancer and Nutrition database to study the relationship between diet, lifestyle, environmental factors and cancer. Dietary intake data was obtained by questionnaire and cancer data from cancer registries. Cox regression was used for analysis and separate analyses were conducted for localized and advanced disease, and also for low-grade and high-grade cancer.

A total of 2,722 men were diagnosed with CaP from a total of 142,520 participants at an average of 8.7 years of follow-up. The median age at diagnosis was 66 years. Protein intake was derived from meat in 32%, cereals in 18%, cheese in 9%, and milk in 7%. Dietary calcium was largely from dairy products (53%). There was a strong correlation between dairy protein and dairy calcium intake. There was no association between meat, fish or eggs and risk of CaP. Dairy products and yoghurt had an increased risk (HR1.17 for the highest vs. lowest fifth of intake). A similar risk was found for total dietary calcium intake and calcium intake from dairy foods. Calcium from non-dairy foods was not associated with CaP risk. An increment of 35g/day of dairy protein was associated with an HR of 1.32. No statistical difference was found for localized vs. advanced disease but there was an association for high-grade CaP (HR1.76).

Allen NE, Key TJ, Appleby PN, Travis RC, Roddam AW, Tjønneland A, Johnsen NF, Overvad K, Linseisen J, Rohrmann S, Boeing H, Pischon T, Bueno-de-Mesquita HB, Kiemeney L, Tagliabue G, Palli D, Vineis P, Tumino R, Trichopoulou A, Kassapa C, Trichopoulos D, Ardanaz E, Larrañaga N, Tormo MJ, González CA, Quirós JR, Sánchez MJ, Bingham S, Khaw KT, Manjer J, Berglund G, Stattin P, Hallmans G, Slimani N, Ferrari P, Rinaldi S, Riboli E

Br J Cancer. 2008 Apr 1 (Epub ahead of print) doi: 10.1038/sj.bjc.6604331

Reported by UroToday.com Contributing Editor Christopher P. Evans, MD, FACS

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