West Nile Virus Epidemic Expected In US Again This Summer
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Article Date: 23 Jun 2008 - 11:00 PDT
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Lyle Petersen, West Nile Virus (WNV) expert at the US Centers for Disease Control and Prevention told CNN he expects this year's West Nile Virus epidemic to be the same as the last four years.
Petersen, who is director of the CDC's division of vector borne diseases was bitten by a WNV carrying mosquito himself five years ago when he walked down his drive at his home in Fort Collins, Colorado, to fetch the newspaper. The world-renowed WNV expert realized what was happening within hours and his suspicions were confirmed with a blood test. He told CNN:
"From my own experience, I can tell you it's not a very mild illness," he said, "It will ruin your summer."
The symptoms of WNV usually emerge between 3 and 14 days after being bitten and range from mild to severe.
Some people feel nothings, while others report feeling very sick. Those who get quite sick can end up in hospital for several days, with high fever, headache and body aches. It can feel like having really bad flu, and they can be in bed for about one to two weeks and emerge feeling very weak. It can take several months for them to get their strength back.
Petersen, who is a long-distance runner, said he knew he had the virus when he felt very weak when he went out for a run.
"About halfway through one of my runs, I felt terrible," he said. "Within a couple of hours, I was lying in bed with severe headaches, eye pain, muscle pain and fever, which lasted about a week." He said he couldn't get out of bed for a week. Petersen said some patients can develop a severe and sometimes fatal neurological disease from WNV.
His daughter and neigbour also got sick, and they remembered being in a mosquito swarm at the mailbox at the bottom of the drive.
West Nile Virus, which emerged nine years ago in the US, is carried by mosquitoes that get it from feeding on infected birds. They pass it onto humans through mosquito bites.
According to various media reports, experts say there will be another epidemic of WNV in the US this summer, in much the same proportions as every summer for the past four years. Petersen told the press he doesn't expect this year to be any different.
The best way to stop WNV, for which there is no effective treatment and a vaccine is years away, said Petersen, is through prevention, such as wearing mosquito repellent, especially at peak times for mosquito biting, dawn and dusk. Repellent sprays containing up to 50 per cent DEET are recommended, but check the label before putting it on your kids.
You can also spray clothing with permethrin-containing repellents, but don't put that directly onto skin.
Other possibilities are natural products such as oil of lemon eucalyptus CQ.
Reparing window and door screens can reduce the chances of WNV carrying mosquitoes entering your home, and eliminating standing water around the home is also an effective prevention measure. Even an upturned plant pot can collect enough rainwater to breed mosquitoes. People should check for standing water regularly, and empty bird baths, rain barrels, buckets, anything that provides a suitable breeding ground for mosquitoes.
Petersen told CNN, even with precautions, WNV won't be eradicated for a while.
"I think West Nile virus is here to stay, and I can't tell you how many cases will occur this summer, but there will be epidemics," he said.
The WNV season usually peaks between mid-July and mid-September. Petersen said around 1.5 million people have been infected so far in the US, and about 300,000 have had West Nile fever.
Click here for more information on West Nile Virus from the CDC (make sure you read the Repellent Updates for safe use of pesticides).
Sources: CNN, CDC.
Written by: Catharine Paddock, PhD
Copyright: Medical News Today
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Promising WNV Rx For Past 5 Yrs
posted by Dave Moskowitz MD on 23 Jun 2008 at 2:01 pm“Yeah, right!” you're thinking. How effective could a treatment be if it's been around since 2003 but no one’s ever heard of it?
The story says more about public health nowadays than you might care to know.
My biotech company, GenoMed, has had encouraging results treating West Nile virus encephalitis since 2003: 81% treatment success rate in people (22 of 27), 75% in horses (6 of 8), and 50% in birds (6 of 12).
Our approach works best when people first have symptoms of a fever and headache. But we’ve been able to help people even a few years after the initial episode of WNV encephalitis.
Our first 8 WNV patients were published in a peer-reviewed medical journal in 2004 (1). We’re eager to see if our approach works again this year. A HIPAA-compliant spread-sheet of our clinical experience to date is available upon request.
Publication in a peer-reviewed medical journal is all it takes for a treatment to officially (i.e. medicolegally) exist.
The drugs we use are already approved by the FDA for blood pressure. Amazingly enough, they’re anti-inflammatory, too. Contrary to popular belief, normal people who get sick from the West Nile virus have too strong an immune response to the virus, not a weak immune system. Our approach is meant to gently calm down their exaggerated immune response, the so-called “cytokine storm.” It can be used in the very old, the very young, and everybody in between.
Although our approach is highly controversial among human virologists (the CDC, for example, thinks all WNV patients have a weakened immune response), veterinarians have no problem with it. They were treating WNV in horses with non-steroidal anti-inflammatory drugs before we came along. We target a step further upstream in the inflammation pathway, and have saved horses that non-steroidal drugs were failing.
But because the CDC doesn't believe us, you've never heard of us. The CDC tells any reporter who asks that they've never heard of us, or that we're making up our data. I know this because I checked back with reporters after they failed to print the story. State epidemiologists all take their cue from the CDC. Reporters for the past 5 summers have chosen to believe the prestigious CDC rather than a for-profit start-up like GenoMed.
I fully understand. But reporters seem to have forgotten the lesson of FEMA. Just because a federal agency is entrusted with the public's health, doesn’t mean it can, or will, deliver. And just because you expect the government to tell the truth, doesn’t mean it will.
The irony gets even heavier, I’m afraid. I just read today that Lyle Peterson, the CDC’s point man for WNV, actually got infected himself with the virus. I don’t know why, but he never tried our treatment. This illustrates perfectly the problem with the CDC’s current approach of just saying “No” to mosquitoes: it's useless advice once you've been bitten. Fortunately, Dr Peterson wasn’t paralyzed. I just left a voice message for him and emailed him offering to try to treat any lingering symptoms. With WNV, there often are, such as fatigue, headache, weakness, etc.
In principle, our approach could be used for almost any virus except the herpes viruses, which seem to do the opposite of other viruses, inducing a state of immune suppression, not immune over-reaction. This is why our approach was included in the BioShield II Act of April 28, 2005, co-sponsored by Senators Lieberman, Hatch, and Brownback. The bill was never debated, but our approach was mentioned in Section 2151 (http://www.govtrack.us/congress/billtext.xpd?bill=s109-975). In 2004, I briefed the White House and the Dept of Homeland Security about it. The UN is aware of our approach in the context of bird flu.
The drugs we use cost about $1 a tablet. We use one or two pills a day. They’re carried in every drugstore on earth.
Anybody who wants to download our WNV trial protocol can do so for free at any time by clicking on the "West Nile trial" link on our company’s homepage at http://www.genomed.com.
Reference
1: Moskowitz DW, Johnson FE. The central role of angiotensin I-converting enzyme in vertebrate pathophysiology. Curr Top Med Chem. 2004;4(13):1433-54. PMID: 15379656 (For PDF file, click on paper #6 at: http://www.genomed.com/index.cfm?action=investor&drill=publications) -- see Table 2 for WNV patients
Sincerely yours,
Dave Moskowitz MD FACP
CEO, GenoMed, Inc.
http://www.genomed.com
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