Prognostic Value Of Re-TURB Of High Risk Non Invasive Bladder Cancer

Main Category: Urology / Nephrology
Also Included In: Cancer / Oncology
Article Date: 28 Jun 2008 - 3:00 PST

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ORLANDO, FL (UroToday.com) - The authors evaluated the usefulness of second TURB and whether pathological outcomes of ReTUR have a prognostic impact on recurrence and progression of primitive T1G3 bladder cancer.

In this study patients with newly diagnosed T1G3 Transitional cell carcinoma of bladder underwent ReTUR 4-6 weeks following the initial TUR. Patients with muscle invasive disease underwent radical cystectomy; those with superficial residual (SRT) and those with no residual tumor (NRT) received a intravesical BCG therapy. In order to evaluate the prognostic significance of ReTUR outcomes, the authors compared recurrence rate, progression rate and recurrence free survival in SRT patients and NRT patients at restaging TUR.

From January 2002 to March 2007 91 patients were enrolled in the study. Restaging TUR revealed residual cancer in 48% of patients. At mean follow up of 27.2 19,8 months, there was statistically significant difference in recurrence rate, progression rate and disease-free survival between no residual tumor patients and patients with non-invasive residual disease (see table)

The authors conclude that ReTUR of T1G3 TCC allows identification of patients with residual and understaged tumors. The outcomes of ReTUR have a prognostic impact on recurrence rate and disease-free survival.

Presented by Roberto C Sanseverino, MD, Antonio Campitelli, MD, Giorgio Napodano, MD, Antonio Barela, MD, Giuseppe Contaldo, MD, at the Annual Meeting of the American Urological Association (AUA) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA.

Reported by UroToday.com Contributing Editor David P. Wood, MD

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