International Team Locates Key Player In Muscle Regeneration

Main Category: Neurology / Neuroscience
Also Included In: Genetics;  Biology / Biochemistry
Article Date: 28 Jun 2008 - 0:00 PDT

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A new understanding of the role played by the protein cdk9-55 in muscle regeneration and differentiation may lead to novel therapies to rebuild muscle tissue damaged by disease, injury and aging, according to researchers at the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University in Philadelphia and the University of Siena.

Adult skeletal muscle tissue can regenerate in response to direct injury, neurological dysfunction and genetic defects. This healing process begins with an activation of muscle stem cells, known as satellite cells. Once activated, the satellite cells multiply and then differentiate into specific types of muscle fibers that eventually fuse to reconstitute muscle tissue.

The researchers discovered that cdk9-55, a variation of the gene cdk9, is induced specifically when satellite cells begin differentiation and is necessary for the genetic reprogramming required to complete the muscle tissue regeneration process.

"By administering cdk9-55 or a protein encoded by a cdk9-55 gene directly to the muscle or on a resorbable material applied to injured or diseased muscle tissue or to an area missing muscle tissue, we can regenerate muscle," said lead researcher Cristina Giacinti, a researcher at the Sbarro Institute and the Department of Histology and Medical Embryology, University of Rome "Sapienza" in Rome, Italy.

Researchers also found that cdk9-55 can be used to increase muscle tissues in healthy tissue.

"This discovery has important implications for tissue regeneration in muscle tissue damaged by disease and injury, genetic disorders such as muscular dystrophy, chronic disorders like cancer or HIV that may impair muscle regeneration, and diseases related to aging," said Antonio Giordano, M.D., Ph.D., the Director of the Sbarro Institute, President of the Sbarro

Health Research Organization, Professor of Molecular Biology at Temple University's College of Science and Technology in Philadelphia, PA, and full professor Pathological Anatomy and Histology of the University of Siena, Italy.

The Sbarro Health Research Organization (http://www.shro.org) and the National Institutes of Health supported the study.

About the Sbarro Health Research Organization

Sbarro Health Research Organization is committed to excellence in basic genetic research to cure and diagnose cancer, cardiovascular diseases, diabetes and other chronic illnesses and to foster the training of young doctors in a spirit of professionalism and humanism.

Sbarro Health Research Organization
http://www.shro.org