The Influence Of Statin Medications On PSA Velocity In Healthy Men

Editor's Choice
Main Category: Statins
Also Included In: Prostate / Prostate Cancer;  Urology / Nephrology;  Men's health
Article Date: 30 Jun 2008 - 0:00 PDT

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ORLANDO, FL (UroToday.com) - Data is emerging about use of statins and risk reduction in development of prostate cancer (CaP). How do statins affect PSA?

The authors previously observed that PSA levels decreased upon initiation of statin medications.

In this report Hamilton and colleagues examined influence of statin drugs on PSA velocity in healthy men. 305 male veterans who did not have prostate cancer, who were prescribed a statin between 1994 and 2006, and who had an adequate number of PSA values on record (at least 2 values before and after the start of statins) were included in the analysis.

PSA values before and after the start of statins were compared. With statin use, median decline in PSA levels was 5.9% (p<0.001). Initiation of statins, however, did not have an influence on PSA velocity (0=0.51). Statin dose did not have an influence on PSA.

The authors conclude that although statins initially lower PSA, these drugs do not have an effect on overall trends in PSA levels.

Presented by Robert J Hamilton, MD, Elizabeth A Platz, MD, Kenneth C Goldberg, MD, and Stephen J Freedland, MD, at the Annual Meeting of the American Urological Association (AUA) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA.

Reported by UroToday.com Contributing Editor Alexander Kutikov, MD

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