The Ratio Of Serum Testosterone To Prostate Specific Antigen Predicts Prostate Cancer In Hypogonadal Men

Main Category: Prostate / Prostate Cancer
Also Included In: Urology / Nephrology;  Cancer / Oncology
Article Date: 30 Jun 2008 - 1:00 PST

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ORLANDO, FL (UroToday.com) - Dr. Abraham Morgentaler and colleagues examined the relationship between testosterone (T) levels and PSA in hypogonadal men.

184 patients with symptomatic hypogonadism (T <300 ng/dL) and PSA of ≤4.0 ng/mL were included in the study. All patients underwent a prostate biopsy prior to initiation of androgen supplementation therapy. A total of thirty patients had adenocarcinoma present on prostate biopsy. T/PSA ratios were calculated after T levels were converted from ng/dL to ng/mL (e.g. 270 ng/dL=2.7 ng/mL). Logistic regression multivariate analysis revealed that T/PSA, but not PSA alone, was strongly associated with cancer risk. Men with lower T/PSA ratios were at higher risk for having prostate cancer on biopsy.

Authors propose a threshold of 1.8 to define abnormal T/PSA ratio, as men whose T/PSA ratios were below this value had a greater than 3-fold risk of being diagnosed with prostate cancer on biopsy.

Presented by Abraham Morgentaler, MD, Charles E Riedner, MD, and Ernani L Rhoden, MD, at the Annual Meeting of the American Urological Association (AUA) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA.

Reported by UroToday.com Contributing Editor Alexander Kutikov, MD

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