Mathematical Models Of Energy Homeostasis

Main Category: Obesity / Weight Loss / Fitness
Also Included In: Diabetes;  Biology / Biochemistry
Article Date: 10 Jul 2008 - 5:00 PDT

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To tackle diabetes and obesity, clinicians are now turning to mechanism-based mathematical models to reach quantitative diagnoses of insulin resistance, glucose intolerance and obesity, and to predict the likely outcomes of therapeutic interventions.

A massive range of such models is available, which renders a judicious choice difficult. To better inform this choice, we here present the most important models published to date in a uniform format, discussing similarities and differences in terms of the decisions faced by modellers.

We review models for glucostasis, based on the glucose-insulin feedback control loop, and consider extensions to long-term energy balance, dislipidemia and obesity.

Journal of the Royal Society Interface

Journal of the Royal Society Interface is the Society's cross-disciplinary publication promoting research at the interface between the physical and life sciences. It offers rapidity, visibility and high-quality peer review and is ranked fifth in JCR's multidisciplinary category.

Journal of the Royal Society Interface