Dynamics Of Hematopoiesis Across Mammals

Main Category: Biology / Biochemistry
Article Date: 16 Jul 2008 - 0:00 PDT

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Hematopoiesis is the process responsible for blood cell formation. At the root of this process lie hematopoietic stem cells.

The demands for hematopoietic output vary across mammals, where the number of active hematopoietic stem cells scales with mass. Hematopoietic stem cells can be linked with the circulating blood with a model based on human data.

By combining these two models, we determined hematopoietic output for various mammals.

The close correlation with experimental data, support the notion that hematopoiesis emerged once in evolution and has a similar architecture across all mammals.

Proceedings of the Royal Society B: Biological Sciences

Proceedings B is the Royal Society's flagship biological research journal, dedicated to the rapid publication and broad dissemination of high-quality research papers, reviews and comment and reply papers. The scope of journal is diverse and is especially strong in organismal biology.

www.publishing.royalsociety.org/proceedingsb