Tumor Growth Significantly Inhibited When Tumor Blood Flow Is Interrupted Following Radiotherapy

Main Category: Cancer / Oncology
Also Included In: Radiology / Nuclear Medicine
Article Date: 24 Jul 2008 - 1:00 PST

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Vascular disrupting agents (VDA) are a new class of anti-cancer drugs which obliterate all vessels in tumors and prevent nutrient supply to the tumor, thereby leading to necrosis of solid tumors.

To clarify the therapeutic significance of interrupting tumor blood flow after radiotherapy, researchers administered a powerful VDA (AC7700), on rats after irradiation.

AC770 completely destroyed the microcirculation at any time after the irradiation and inhibited tumor regrowth. In addition, the radiotherapy efficacy was significantly enhanced when combined with AC7700 - strongly suggesting that the combination was very effective in preventing cancer recurrence.

"Tumor blood flow interruption after radiotherapy strongly inhibits tumor growth"
Katsuyoshi Hori, Shozo Furumoto, Kazuo Kubota
Cancer Science Volume 99 Issue 7, Pages 1485 - 1491
DOI 10.1111/j.1349-7006.2008.00834.x
Click here to view Abstract online

About Cancer Science

Cancer Science (formerly Japanese Journal of Cancer Research) aims to present research that has a significant clinical impact on oncologists or that may alter the disease concept of a tumor. The Journal publishes original articles and editorials, letters to the editor, review articles and reports describing original research in the fields of basic, translational and clinical cancer.

Subject categories include:
-- carcinogenesis
-- tumor biology and pathology
-- molecular biology and genetics
-- epidemiology and prevention
-- immunology and virology
-- experimental therapeutics
-- clinical medicine

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