Cancer Research UK Expresses 'deep Concern' On Kidney Cancer Drug Decision

Main Category: Cancer / Oncology
Also Included In: Urology / Nephrology
Article Date: 07 Aug 2008 - 5:00 PDT

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Cancer Research UK is very disappointed with NICE's decision to reject four kidney cancer drugs*.

Following a preliminary review, NICE has ruled that although these drugs are clinically effective, they are not good value for money for the NHS.

Metastatic renal cell carcinoma is a rare form of kidney cancer so there is limited, but robust, clinical data on the best way to treat it and very few treatment options for the disease. But doctors think that because these new drugs could extend a patient's life, they should have the option to have these treatments.

Cancer Research UK - the largest publicly funded research charity in the UK - wants to see the way NICE review the value of drugs altered for rare diseases, such as this type of kidney cancer, where clinical benefit is proven but evidence is limited.

Professor Peter Johnson, Cancer Research UK's chief clinician, said: "We are disappointed at NICE's view that although these drugs are clinically effective, their high price means that they are not considered to be value for money for the NHS. These drugs have shown a small but definite improvement in an illness where there are few alternative treatments. If this decision stands it will be very frustrating for cancer patients and their clinicians.

"This decision once again raises questions about whether NICE's system of appraisal is appropriate for all types of drugs. It is often difficult to get unequivocal research data in rarer cancers, such as metastatic kidney cancer, which have a small patient population. Although we understand that NICE often has to make difficult decisions, in this case there is a clear separation between what NICE finds to be valuable treatment, and clinical and patient opinion. Action is needed to bring these two positions closer together."

Harpal Kumar, chief executive of Cancer Research UK, said: "Possible solutions include looking at the way that pharmaceutical companies are charging the NHS for drugs, and whether appropriate allowances are being made by NICE to compensate for the lack of large scale trials in these areas. We also need to ensure that further results are sought and that larger trials, in addition to the nine studies supported by Cancer Research UK, are carried out."

Cancer Research UK will be expressing its concern to NICE and is keen to seek the views of the public on this decision. We are asking the public to share their views on our website.

Notes

* bevacizumab, sorafenib, sunitinib and temsirolimus.

Anyone with questions about cancer or its treatment, including kidney cancer, can visit our patient information website CancerHelp UK or contact our cancer information nurses here.

About Cancer Research UK

- Together with its partners and supporters, Cancer Research UK's vision is to beat cancer.

- Cancer Research UK carries out world-class research to improve understanding of the disease and find out how to prevent, diagnose and treat different kinds of cancer.

- Cancer Research UK ensures that its findings are used to improve the lives of all cancer patients.

- Cancer Research UK helps people to understand cancer, the progress that is being made and the choices each person can make.

- Cancer Research UK works in partnership with others to achieve the greatest impact in the global fight against cancer.

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