Use Of Tolterodine In Children With Neurogenic Detrusor Overactivity: Relationship Between Dose And Urodynamic Response

Main Category: Urology / Nephrology
Also Included In: Pediatrics / Children's Health
Article Date: 28 Aug 2008 - 3:00 PST

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UroToday.com - This study by Dr. Pramod Reddy et al. evaluated the use of tolterodine in children with neurogenic detrusor overactivity. The efficacy of the drug was evaluated urodynamically and using parent-completed 3-day bladder diaries. The study was done prospectively. They received drug formulation and dosing based on age.

They found that functional bladder capacity increased within one year in the younger patients but not in the older patients. The first contraction in detrusor leak point pressure did not change in any age group. The number of incontinence episodes decreased for all the patients, as did the number of catheterizations utilized in the 24-hour period to keep dry. The mean volume per catheterization increased in all subjects. Seven of the 30 subjects who were enrolled showed treatment-related adverse events.

The group concluded that tolterodine formulations were effective and well tolerated in children with neurogenic detrusor overactivity. This is a helpful first step since the long-acting tolterodine might play a role for these children once the short-acting dose is tolerated.

Ellsworth PI, Borgstein NG, Nijman RJ, Reddy PP
J Urol. 2005 Oct;174(4 Pt 2):1647-51
doi:10.1097/01.ju.0000176622.81796.89

Reported by UroToday.com Medical Editor Pasquale Casale, MD

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