Search is Powered by Google
Cardiovascular / Cardiology News

Omega-3 Polyunsaturated Fatty Acids Reduce Mortality And Hospital Admission In Patients With Heart Failure, Statins Show No Effect

Main Category: Cardiovascular / Cardiology
Also Included In: Statins;  Nutrition / Diet
Article Date: 31 Aug 2008 - 4:00 PDT

email icon email to a friend   printer icon printer friendly   write icon view / write opinions   rate icon rate article


Current Article Ratings:

Patient / Public:4 and a half stars

4.3 (10 votes)

Health Professional:5 stars

5 (4 votes)

Article Opinions: 0 posts

A simple, safe, one-a-day capsule of omega-3 polyunsaturated fatty acids (PUFA) can reduce mortality and admission to hospital for cardiovascular reasons in patients with heart failure. These are the conclusions of the first of two Articles based on the GISSI-HF* study published early Online and in an upcoming edition of The Lancet. The second Article concludes that statin treatment with rosuvastatin does not affect clinical outcomes in patients with chronic heart failure. Both Articles are being presented at the European Society of Cardiology meeting in Munich.

In the first Article Professor Luigi Tavazzi and Professor Gianni Tognoni , GISSI-HF Coordinating Centre, ANMCO Research Centre, Florence, Italy and Mario Negri Institute, Milan, Italy and colleagues from the GISSI-HF investigators discuss the results of a randomised controlled trial from 357 cardiology sites in Italy, which looked at patients with chronic heart failure. Patients received either omega-3 PUFA in a capsule once daily (3494 patients) or placebo (3481). 955 patients in the PUFA group (27%) died, compared with 1014 (29%) in the placebo group-meaning a relative risk reduction of 9% in the PUFA group. A higher proportion of patients in the placebo group (2053/59%) died or were admitted to hospital for cardio-vascular reasons than in the PUFA group (1981/57%)-a relative reduction of 8% in the PUFA group. In absolute terms, 56 patients needed to be treated with PUFA for just under four years to avoid one death, or 44 patients to avoid one event of either death or admission to hospital for cardiovascular causes. Gastrointestinal disorders were the most frequent adverse reaction, and were experienced by 3% of patients in both groups. The authors conclude: "Our study shows that the long-term administration of 1 g per day omega-3 PUFA was effective in reducing both all-cause mortality and admissions to hospital for cardiovascular reasons."

The second Article based on GISSI-HF, by the same authors, discusses the results of a randomised controlled trial from the same 357 cardiology sites in Italy, which looked at the effect of the statin drug rosuvastatin in patients with heart failure. Patients received either rosuvastatin 10 mg daily (2285 patients) or placebo (2289), and were followed up for a median of nearly four years. The researchers found that 657 patients (29%) died from any cause in the rosuvastatin group, compared with 644 (28%) in the placebo group. Proportions of patients who died or were admitted to hospital for cardiovascular causes were also similar in both groups (1305/57% rosuvastatin versus 1283/56% placebo). Again, gastrointestinal disorders were the most common adverse events in both groups (1% rosuvastatin versus 2% placebo). The authors conclude: "Rosuvastatin 10 mg daily did not affect clinical outcomes in patients with chronic heart failure of any cause, in whom the drug was safe."

In an accompanying Comment, Dr Gregg Fonarow, Ahmanson-UCLA Cardiomyopathy Center, Los Angeles, CA, USA, says: "For omega-3 fatty acid supplementation, benefits observed in other populations apply to patients with heart failure. For statins, the benefits, unfortunately, seem not to. Although other promising treatments for heart failure are under investigation, every effort should be made apply those therapies which are evidence-based to all eligible patients with heart failure."

*GISSI-HF stands for Gruppo Italiano di Studio della Sopravvivenza nella Insufficienza cardiac-Heart Failure.

The Lancet




Personalized Homepage Weekly Newsletters Daily News Alerts
Opioid Induced Constipation ADHD Anxiety Asthma Autism Cancer Diabetes Lung Cancer Lupus Medicare / Medicaid Obesity and BMI Pancreatic Cancer Stem Cells All 'What Is...' Articles All 'How To...' Articles

Ophthalmology Urology
About Us News Licensing Free Website Feeds Free Tools & Content Tell a Friend Accessibility Help / FAQ Article Submission Links Contact Us

add medical news today to your facebook
medical news gadget

Swine Flu Image

Swine Flu Updates

- Latest Swine Flu News
- What is Swine Flu?
- Map Of H1N1 Outbreaks
- Swine Flu - Top 20 FAQ
- Daily Email News Alerts
Stick with Medical News Today for the latest news updates on swine flu.


These are the most read articles from this news category for the last 6 months:
Top Article Star
Stress Can Be The Cause Of Unexplained Chest Pain
10 Feb 2009
Each year, many people seek emergency treatment for unexplained chest pains. A thesis from the Sahlgrenska Academy, University of Gothenburg, Sweden, indicates several common factors among those affected, including stress at...


Talking with Your Doctor image Talking with Your Doctor

Talking with your doctor can sometimes be difficult. Good health care, however, depends on an open dialogue between patients and doctors...

Keeping a Personal Medical Record image Keeping a Personal Medical Record

Medical information is usually scattered in many different places. To receive the best possible health care, people are encouraged to gather information in one place and create a personal medical record...

View more videos...