Recombinant MOG Proteins - New

Main Category: Biology / Biochemistry
Article Date: 09 Sep 2008 - 3:00 PDT

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Expanding on its world-class collection of MOG peptides and assay kits, AnaSpec is pleased to announce the release of 3 MOG recombinant proteins, for human, mouse and rat.

These proteins, with sequences corresponding to human, mouse and rat extracellular domain, together with a 6x His tag were expressed in E. coli and purified from urea denatured bacterial lysate. The molecular weight found in all 3 recombinant proteins was 14.23 kDa. The activity of these proteins was checked for their ability to induce EAE in either mouse (for the human and mouse rMOGs) or rat (for rat rMOG).

About AnaSpec

AnaSpec is a leading provider of integrated proteomics solutions to the world's largest biotech, pharmaceutical, and academic research institutions. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents (including antibodies, dyes, and assay kits), and combinatorial chemistry.

References

1. Linares, D. et.al. Protein Expression and Purif. 34, 249 (2004).
2. Bettadapura, J. et.al. J. Neurochem. 70, 1593 (1998).
3. Oliver, AR. et al J. Immunol. 171, 462 (2003).
4. Von Budingen, H. et.al. J. Clin. Immunol. 21, 155 (2001).
5. Lyons, J. et.al. Eur. J. Immunol. 29, 3432 (1999)
6. Von Budingen, H. et.al. Eur. J. Immunol. 34, 2072 (2004).

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