Results Of The National CT Colonography Trial Raise Questions For Patients

Main Category: Cancer / Oncology
Also Included In: GastroIntestinal / Gastroenterology;  Radiology / Nuclear Medicine;  Endocrinology
Article Date: 19 Sep 2008 - 3:00 PDT

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Results of the National CT Colonography Trial, published in the September 18 issue of the New England Journal of Medicine, show improvements in the technology's ability to diagnose intermediate- to large-sized polyps in the colon, but this method of testing is not as effective in diagnosing small polyps. CT colonography is one of several colorectal cancer screening options. The American Society for Gastrointestinal Endoscopy (ASGE) encourages patients to speak to their doctor about the screening method that is best for them.

"Colorectal cancer is largely preventable and curable when diagnosed in its early stages. Screening saves lives. Unfortunately, far too few people undergo screening for colorectal cancer. Any advances that result in increased screening of the population are encouraging," said ASGE President John L. Petrini, MD, FASGE. "The results of this trial may prompt those who otherwise would have avoided being tested, to get screened for colorectal cancer. With so many different options to screen for colorectal cancer, it is important to talk to your doctor and discuss which screening method is best for you. Each screening option has appropriate applications and limitations."

CT colonography, also referred to as virtual colonoscopy, relies on a computer program to generate a 3D picture of the large intestine (colon) using x-ray images. This differs from colonoscopy, which provides actual photos of the colon and rectum via a camera attached to a thin, flexible scope that is physically guided through the large intestine.

The results of the National CT Colonography Trial have shown some improvements in the ability of CT colonography to diagnose intermediate- to large-sized polyps. Complete data for 2,531 participants at 15 U.S. centers showed that CT colonography identified large colorectal adenomas (polyps most likely to become cancerous) or cancers 10 mm or larger that were detected by colonoscopy in 9 out of 10 asymptomatic patients. The study also showed that CT colonography had a lower sensitivity for smaller colorectal lesions of 6 to 9 mm in size.

Researchers also reported:

• The sensitivity for the detection of adenomas or cancers greater than or equal to 5 mm, 6mm, 7 mm, 8 mm, 9 mm was 65 percent, 78 percent, 84 percent, 87 percent, 90 percent, respectively.
  
  
• If all patients with a lesion measuring 5 mm or more on CT colonography were to be referred for colonoscopy, the colonoscopy-referral rate based on these study results would be 17 percent.

Study participants were asymptomatic, 50 years of age or older and scheduled to undergo routine colonoscopy. Patients were excluded if they had lower abdominal pain, inflammatory bowel disease or familial polyposis syndrome among other exclusionary criteria.

There are, however, concerns about CT colonography's failure to detect small lesions and inability to remove lesions in the colon. Although small polyps often are not cancerous they can be adenomatous polyps and have a risk of developing into cancer. If a polyp is detected through CT colonography, the patient must subsequently undergo a separate colonoscopy to remove the polyp. Most likely, this would happen on another day and the patient would require a second bowel prep before undergoing the colonoscopy.

The primary end point of this study was detection by CT colonography of large adenomas or cancers 10 mm or larger. The radiologists making the interpretations were instructed to record only lesions measuring 5 mm or more in diameter.

It has been suggested that patients with small polyps may be followed by CT colonography at shorter intervals, without referral for colonoscopic removal. This approach of leaving polyps behind has not been tested and it is important to recognize that even small polyps can infrequently harbor early or advanced cancer. Follow up CT examinations will also expose patients to cumulative doses of radiation. Data published in the New England Journal of Medicine (Nov. 29, 2007), pointed to the potential dangers of radiation exposure over a person's lifetime from diagnostic medical testing using CT scans. Recent articles in Time (June 27, 2008) and the New York Times (June 29, 2008) also noted the radiation risks of CT scans. CT colonography could negatively impact the cost-effectiveness of colorectal cancer screening, as each positive CT colonography will require a subsequent colonoscopy.

"ASGE supports colonoscopy for colorectal cancer screening because it offers the advantage of allowing for detection and prevention through the removal of polyps during the same procedure, without unnecessary radiation exposure. Colonoscopy also has a high detection rate for polyps of all sizes and is the only method that allows us to remove polyps before they turn into cancer," said Petrini.

According to a study released in October 2007 from the Centers for Disease Control and Prevention and the American Cancer Society, colorectal cancer deaths dropped nearly 5 percent between 2002 and 2004, more than the other major cancer killers (prostate, breast, lung). Among the key factors playing a role in the decline was prevention through screening and the removal of precancerous polyps. This is excellent news and reinforces the importance of colorectal cancer screening beginning at age 50, or even younger if there is a family history of colorectal cancer or polyps.

If CT colonography is a method patients are considering, they must understand its limitations:

• Requires the same bowel prep as colonoscopy.
  
  
• Does not detect small polyps.
  
  
• Does not have the ability to remove polyps.
  
  
• Requires the insertion of a small tube in the rectum and insufflation of air into the colon.
  
  
• Does not require sedation, although air distension of the bowel can be uncomfortable.
  
  
• Exposes the patient to radiation.
  
  
• Is not currently covered by Medicare as an initial screening test.
  
  
• Results from a few select specialized centers have not been replicated elsewhere.
  
  
• Currently there is a shortage of people trained to read these scans.

"CT colonography may be best in low risk patients who cannot undergo colonoscopy or who have had an incomplete colonoscopy due to various factors," said Petrini. "Colorectal cancer prevention is a major priority for ASGE, by whichever form it is achieved. Not enough people are getting screened for colorectal cancer and opening a dialogue about screening between the physician and patient is crucial in preventing this disease. Therefore, we will continue to follow developments in all modes of colorectal cancer screening and to critically evaluate which methods are best for patients."

Before undergoing a CT colonography, here are some questions to ask the physician who will perform the procedure:

• What training have you received to perform CT colonography?
  
  
• How many CT colonographies have you performed?
  
  
• What are complications of the procedure?
  
  
• What arrangements will be made if I have a significant finding?

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Article adapted by Medical News Today from original press release.
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For more information about colorectal cancer screening, visit ASGE's colorectal cancer awareness Web site at www.screen4coloncancer.org.

About the American Society for Gastrointestinal Endoscopy

Founded in 1941, the mission of the American Society for Gastrointestinal Endoscopy is to be the leader in advancing patient care and digestive health by promoting excellence in gastrointestinal endoscopy. ASGE, with more than 10,000 physician members worldwide, promotes the highest standards for endoscopic training and practice, fosters endoscopic research, recognizes distinguished contributions to endoscopy, and is the foremost resource for endoscopic education. Visit http://www.asge.org/rg and http://www.screen4coloncancer.org/ for more information.

About Endoscopy

Endoscopy is performed by specially-trained physicians called endoscopists using the most current technology to diagnose and treat diseases of the gastrointestinal tract. Using flexible, thin tubes called endoscopes, endoscopists are able to access the human digestive tract without incisions via natural orifices. Endoscopes are designed with high-intensity lighting and fitted with precision devices that allow viewing and treatment of the gastrointestinal system. In many cases, screening or treatment of conditions can be delivered via the endoscope without the need for further sedation, treatment or hospital stay.

Source: Anne Brownsey
American Society for Gastrointestinal Endoscopy