The Effect Of Desmopressin On Renal Water And Solute Handling In Desmopressin Resistant Monosymptomatic Nocturnal Enuresis

Main Category: Urology / Nephrology
Also Included In: Clinical Trials / Drug Trials
Article Date: 19 Sep 2008 - 9:00 PST

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UroToday.com - Dr. Konstantinos Kamperis, et al. evaluated the effect of clinically administered desmopressin on renal water and solute handling in children with monosymptomatic nocturnal enuresis and desmopressin-resistant nocturnal polyuria - compared to healthy controls.

The group was comprised of a total of 12 patients with normal bladder function and capacity but with enuresis and nocturnal polyuria unresponsive to desmopressin. 10 age-matched controls were also enrolled in the study. The children were admitted to the hospital for a 48-hour protocol that included urine collections and blood sampling.

The group found that desmopressin markedly reduced nocturnal urine output in patients with enuresis, minimizing sodium, urea, and overall solute excretion, despite the fact that these children were unresponsive to desmopressin at home.

They concluded that children with nocturnal enuresis and nocturnal polyuria who do not exhibit adequate response to desmopressin at home, respond well to the agent at the clinic. They did not have a clear answer to why this occurred. They did find the effect of desmopressin in children with enuresis seems largely dependent on reductions in the amount of sodium excreted. From this study, one may postulate that trying a low sodium diet might be helpful in these children.

Kamperis K, Rittig S, Radvanska E, Jørgensen KA, Djurhuus JC
J Urol. 2008 Aug;180(2):707-13
doi:10.1016/j.juro.2008.04.047

Written by Pasquale Casale, MD for UroToday.com

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