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Study Finds Antioxidant Deficiency Linked To Pulmonary Hypertension

Main Category: Cardiovascular / Cardiology
Also Included In: Hypertension
Article Date: 24 Sep 2008 - 1:00 PDT

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A recent study shows that a loss of antioxidants in the endothelial cells that line blood vessels in the lungs contributes to the loss of vasodilator effects and, ultimately, to the development of pulmonary hypertension. The findings appear in Clinical and Translational Science.

The study, led by Serpil Erzurum of the Cleveland Clinic, evaluated antioxidant activities in patients with idiopathic pulmonary arterial hypertension (IPAH), a fatal disease characterized by progressive increase in pulmonary artery pressure and vascular resistance.

Erzurum's study found that the inactivation of these oxidants inside the cell is achieved mainly by the cell's own line of defense against oxidants. Additionally, the researchers determined that this process may contribute to low levels of nitric oxide, identified in IPAH and a fundamental component in the pathogenesis of pulmonary hypertension.

According to Dr. Erzurum, there is a potential long-term benefit to the care of patients with IPAH due to the study's findings. "Antioxidant augmentation in patients might be used to increase nitric oxide vasodilator effects, reduce pulmonary artery pressures and potentially improve clinical outcomes," she said.

To view the abstract for this article, please click here.

Clinical and Translational Science (CTS) is the source for the most current and thought-provoking original research across the broad spectrum of clinical specialties and basic science. CTS highlights investigative work bridging the gap between laboratory discovery and practice. CTS discusses the state-of-the-science and strategies that will accelerate the assimilation of genomics and proteomics information into the clinic.

Wiley-Blackwell was formed in February 2007 as a result of the acquisition of Blackwell Publishing Ltd. by John Wiley & Sons, Inc., and its merger with Wiley's Scientific, Technical, and Medical business. Together, the companies have created a global publishing business with deep strength in every major academic and professional field. Wiley-Blackwell publishes approximately 1,400 scholarly peer-reviewed journals and an extensive collection of books with global appeal.

For more information on Wiley-Blackwell, please visit http://www.blackwellpublishing.com or http://interscience.wiley.com.




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