"Pre-vivors" Beat Cancer To The Punch

Main Category: Breast Cancer
Also Included In: Cancer / Oncology;  Women's Health / Gynecology
Article Date: 14 Oct 2008 - 2:00 PDT

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Armed with the knowledge that they have a defective gene that increases their risk of developing breast cancer, a growing number of women are taking a pre-emptive strike by opting for a bilateral mastectomy (the surgical removal of both breasts). These pro-active women are known as "pre-vivors."

Valerie Gorman, M.D., breast surgeon on the medical staff at Baylor Medical Center at Waxahachie, has seen an increase in pre-vivors in her practice, and she credits several advances for their growing numbers.

"Women today are more educated about their risk factors, and we understand genetics better," said Dr. Gorman. "Plus, genetic testing is easier than in the past, and plastic surgery reconstructive procedures are more accessible."

With genetic testing more readily available, more women than ever are learning if they have a defective BRCA1 or BRCA2 gene. As tumor suppressor genes, these genes are responsible for slowing down cell division. When the BRCA1 and BRCA2 genes are altered, they no longer suppress abnormal growth. Defects in these genes can increase a woman's risk of developing breast cancer by up to 80 percent, according to the American Cancer Society.

However, the risk of breast cancer in women who have mutations in the BRCA1 and BRCA2 genes can be reduced by a dramatic 90 percent through a bilateral mastectomy, according to a 2004 study published in the Journal of Clinical Oncology.

Dr. Gorman points out that it is not only women with identified gene mutations that are opting for a mastectomy for healthy breasts.

"Some women with a high-risk family history decide to have a bilateral mastectomy, and many women who already have breast cancer in one breast decide to have the healthy breast removed to reduce their risk and worry," she said.

For more information about Baylor Medical Center at Waxahachie, visit http://www.BaylorHealth.com.