Transitional Cell Carcinoma: Experimental - Coverage From The 60th Annual Congress Of The German Urological Association

Main Category: Urology / Nephrology
Also Included In: Cancer / Oncology
Article Date: 17 Oct 2008 - 2:00 PDT

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STUTTGART, GERMANY (UroToday.com) - Apoptotic DNA fragments in serum of patients with muscle-invasive bladder cancer are of prognostic relevance.

The authors compared 45 patients with muscle-invasive bladder cancer and 45 patients with BPH. With the aim of RT-PCR, two DNA fragments were identified and found to be present in significantly higher levels in serum of patients with muscle-invasive bladder cancer compared to patients with BPH. Sensitivity was 96% and specificity 62%. Also, the apoptotic index was higher in patients with muscle-invasive bladder cancer. There was no correlation with tumor stage according to TNM.

The authors concluded that the presence of apoptotic DNA fragments in serum of patients with muscle-invasive bladder cancer is a negative prognostic phenomenon.

Abstract #P7.1

Presented by J. Ellinger, MD, et al., at the 60th Annual Congress of the German Urological Association (DGU) - September 24 - 27, 2008 - Stuttgart, Germany

Reported by Christian Doehn, MD, a Contributing Editor with UroToday.com

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