News From The American Chemical Society Oct. 15, 2008

Main Category: Biology / Biochemistry
Also Included In: Cosmetic Medicine / Plastic Surgery;  Dermatology
Article Date: 21 Oct 2008 - 7:00 PDT

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LEDs may help reduce skin wrinkles, researchers report

Researchers in Germany are describing a potential alternative to Botox and cosmetic surgery for easing facial wrinkles. Their study, scheduled for the November 5 issue of ACS' Crystal Growth & Design, a bi-monthly journal, reports that high intensity visible light from light emitting diodes (LEDs) applied daily for several weeks resulted in "rejuvenated skin, reduced wrinkle levels, juvenile complexion and lasting resilience." LEDs are the miniature lights used in an array of products, from TV remote controls to traffic lights.

In the study, Andrei P. Sommer and Dan Zhu point out that high-intensity visible light has been used in medicine for more than 40 years to speed healing of wounds. That light actually penetrates into the skin, causing changes in the sub-surface tissue. Until now, however, scientists have not known the physicochemical nature of those changes.

They report identifying how the visible light works - by changing the molecular structure of a glue-like layer of water on elastin, the protein that provides elasticity in skin, blood vessels, heart and other body structures. Figuratively speaking, the light strips away those water molecules that are involved in the immobilization of elastin, gradually restoring its elastic function and thus reducing facial wrinkles. "We are justified in believing that our approach can be easily converted to deep body rejuvenation programs," the researchers state. - AD

"From Microtornadoes to Facial Rejuvenation: Implication of Interfacial Water Layers"

CONTACT:
Andrei P. Sommer, Ph.D.
University of Ulm
Ulm, Germany

Spinning natural proteins into fabrics for new wound-repair products

Scientists in Israel are reporting the first successful spinning of a key natural protein into strong nano-sized fibers about 1/50,000th the width of a human hair. The advance could lead to a new generation of stronger, longer-lasting biocompatible sutures and bandages to treat wounds. The study is scheduled for the November 10 issue of ACS' Biomacromolecules, a monthly journal.

Eyal Zussman and colleagues point out that researchers have tried for years to develop wound repair materials from natural proteins, hoping that such fibers would be more compatible with body tissue than existing materials. Scientists recently focused on producing these fibers through "electrospinning," a high-tech weaving process that uses electrical charges to draw out nano-sized fibers from a liquid. But the approach has achieved poor results until now.

In the new study, the scientists describe a new method for producing electrospun polymers using bovine serum albumin (BSA), a so-called "globular" protein found in cow's blood. BSA is similar to serum albumin, one of the most abundant proteins in the human body. The method involves adding certain chemicals to a solution of BSA to loosen the bonds that hold these highly-folded proteins together. That results in a thinner, more spinnable protein solution. Using electrospinning, the process resulted in strong fibers that are easily spun into suture-like threads or thick mats resembling conventional wound dressings. This approach is being followed by the groups of Zvi Nevo and Abraham Katzir at Tel-Aviv University, the researchers said, noting that the new method also can be applied to other types of natural proteins. - MTS

"Nanofibers Made of Globular Proteins"

CONTACT:
Eyal Zussman, Ph.D.
Technion-Israel Institute of Technology
Haifa, Israel

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Article adapted by Medical News Today from original press release.
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The American Chemical Society - the world's largest scientific society - is a nonprofit organization chartered by the U.S. Congress and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

Source: Michael Woods
American Chemical Society