During A Response-Imaging Task, MRI Brain Activity In First-Episode Bipolar Mania

Main Category: Bipolar
Also Included In: Psychology / Psychiatry;  MRI / PET / Ultrasound
Article Date: 30 Oct 2008 - 2:00 PDT

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Impulsiveness can be a common feature of mania, particularly the inability to inhibit behavioral responses.

This neuroimaging study examined bipolar patients during their first episode of mania to clarify the brain functioning associated with response inhibition in this early phase of illness.

16 first-episode bipolar patients and 16 healthy subjects were underwent functional MRI scanning (fMRI) while performing a response inhibition task.

Although both groups performed the task at similar levels, the bipolar patients showed decreased activation in the brain regions associated with response inhibition.

"Magnetic resonance imaging brain activation in First-Episode Bipolar Mania during a Response Inhibition Task"
Stephen M. Strakowski, Caleb M. Adler, Michael A. Cerullo, James C. Eliassen, Martine Lamy, David E. Fleck, Jing-Huei Lee, Melissa P. DelBello
Early Intervention in Psychiatry - Nov 4th 2008, DOI: 10.1111/j.1751-7893.2008.00082.x
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The development, onset and treatment of emerging mental disorders

Endorsed by the International Early Psychosis Association

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Focusing on the early diagnosis and treatment of all mental health problems and disorders, Early Intervention in Psychiatry promotes the importance of early intervention in psychiatric practice. Articles across the full range of psychiatric disorders are welcomed, including schizophrenia and other psychoses, mood and anxiety disorders, substance use disorders, eating disorders and personality disorders, as well as the underlying epidemiological, biological, psychological and social mechanisms that influence the onset of these disorders. Papers in the following fields will be considered: diagnostic issues, psychopathology, clinical epidemiology, biological mechanisms, treatments and other forms of intervention, clinical trials, health services and economic research and mental health policy. http://www3.interscience.wiley.com/journal/118501024/home

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