Symptoms In Asthmatic Children Worsened By Traffic Pollution

Main Category: Respiratory / Asthma
Also Included In: Pediatrics / Children's Health;  Water - Air Quality / Agriculture;  Public Health
Article Date: 14 Nov 2008 - 7:00 PST

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Traffic pollution, especially in cities, adversely affects respiratory health in children with asthma. A study published in BioMed Central's open access journal Respiratory Research has found that in this vulnerable group, worsening of respiratory symptoms requiring recurrent additional treatment.

A Mexican research team led by Dr Isabelle Romieu of the Institute Nacional de Sauld Publica, correlated pollutants associated with exacerbation of respiratory symptoms in asthmatic children. Earlier studies suggest that traffic pollution, and diesel particles in particular, may have a greater effect on respiratory health than other pollutants. This is significant as a large proportion of pollution in cities originates from motor vehicles. At present, no studies have clearly linked different types of vehicular traffic exhaust to respiratory health of either asthmatic or healthy children.

147 asthmatic children and 50 non-asthmatic children, between the ages of 6 and 14, were recruited through a paediatric hospital in Mexico City. Parents kept a daily record of coughing and wheezing experienced by their children, as well as medication usage. Atmospheric levels of the pollutants ozone, nitrogen dioxide and diesel particles were recorded in Mexico City during the study. The amount and type of traffic in areas inhabited by the volunteers was also recorded in order to evaluate whether diesel-fuelled vehicles had a greater impact upon respiratory health than pollution from other vehicles.

In asthmatic children, coughing, wheezing and medication usage was associated with increased levels of atmospheric pollutants. In healthy volunteers, increased coughing was only seen with higher levels of nitrogen dioxide. Children living in areas with high levels of traffic more often experienced worsening of asthma symptoms and greater use of medication. Small buses for public transport running on petrol/natural gas, and larger buses and trucks running on diesel, were more strongly associated with worsening of symptoms.

Although oxidative stress has been shown to be a major underlying feature of the toxic effect of air pollutants, there is still a need for a better understanding of the actual mechanisms by which pollutants cause exacerbation of respiratory symptoms. Romieu points out that, all types of traffic exhaust have an adverse effect on children respiratory health and that given the proximity of many schools to roads with heavy traffic, "these results have significant implications for public health policy within cities in Mexico and the rest of the world".

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Article adapted by Medical News Today from original press release.
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Notes:

• Traffic-related air pollution and respiratory symptoms among asthmatic children, resident in Mexico City: The EVA Cohort Study
  Isabelle IR Romieu, Maria-Consuelo CE Escamilla-Nuñez, Albino AB Barraza-Villarreal, Leticia LH Hernandez-Caden, Hortensia HM Moreno-Macias, Matiana MR Ramirez-Aguilar, Juan-Jose JS Sienra-Monge, Marlene MC Cortez, Jose-Luis JT Texcalac Ing and Blanca BR Del-Rio-Navarro
  Respiratory Research
  Article available at the journal website: http://respiratory-research.com/
  All articles are available free of charge, according to BioMed Central's open access policy.
  
  
• Respiratory Research is an Open Access, peer-reviewed, online journal that considers manuscripts on all aspects of respiratory function and disease. Respiratory Research is edited by Jan Lötvall (Göteborg University) and Reynold A Panettieri (University of Pennsylvania). The journal has an Impact Factor of 3.62.
  
  
• BioMed Central (http://www.biomedcentral.com/) is an independent online publishing house committed to providing immediate access without charge to the peer-reviewed biological and medical research it publishes. This commitment is based on the view that open access to research is essential to the rapid and efficient communication of science.

Source: Graeme Baldwin
BioMed Central