Validation Of Heart Failure Risk Model

Main Category: Heart Disease
Also Included In: Cardiovascular / Cardiology;  Seniors / Aging
Article Date: 01 Apr 2009 - 2:00 PDT

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Researchers at Emory University School of Medicine created the Health ABC Heart Failure Model for predicting risk of new onset heart failure in the elderly. Now that model has been strengthened by validating it in a separate library of patient data from an earlier cardiovascular study.

The results suggest the Health ABC risk model can be used to identify high-risk individuals for whom interventions can be targeted cost-effectively to prevent heart failure.

"This is a scoring system that could help individuals or their physicians understand their five-year risk for heart failure, using basic risk factors that are easily obtained at relatively low cost," says Javed Butler, MD, MPH, associate professor of medicine and director of heart failure research at Emory University School of Medicine.

Andreas Kalogeropoulos, MD, a post-doctoral research fellow with Butler, presented the findings at the American College of Cardiology conference in Orlando.

Heart failure is the leading cause of hospitalization in people older than 65 and greatly increases the risk of sudden cardiac arrest.

The Health ABC model uses nine clinical measures to estimate the risk of heart failure in patients who haven't necessarily been seen by doctors for coronary heart disease before. The nine measures are: age, history of coronary heart disease, smoking, blood pressure, heart rate, left ventricular hypertrophy measured by electrocardiography, and blood levels of glucose, creatinine and albumin.

Several individual risk factors for heart failure have been identified, but Butler says the model is the first that combines the risk factors into a system for predicting risk for any given individual. The model categorizes individuals into four risk categories ranging from less than 5 (low) to more than 20 percent (very high) 5-year risk, and has been shown to perform well for men, women, Caucasians and African Americans.

"Considering the high cost of care and poor outcomes for patients who develop heart failure, any effort to identify these individuals early on and facilitate intervention is likely to be of significant benefit," Butler says.

The Health ABC model grew out of the Health Aging and Body Composition Study, which followed 2,935 elderly people in the Pittsburgh and Memphis areas over seven years starting in 1998. The model was validated by assessing it in 5,335 people without pre-existing heart failure from North Carolina, California, Maryland and Pennsylvania who were participants in the Cardiovascular Health Study beginning in 1989.

Butler and his colleagues also are presenting data from the Health ABC study confirming previous work elsewhere showing that blood glucose can predict heart failure risk even in non-diabetics and evaluating the additional information doctors can glean from different measures of blood pressure.

Notes:

Reference for the Health ABC heart failure risk model: Circulation Heart Failure 2008,1:125-133

The Robert W. Woodruff Health Sciences Center of Emory University is an academic health science and service center focused on missions of teaching, research, health care and public service. Its components include schools of medicine, nursing, and public health; the Yerkes National Primate Research Center; the Emory Winship Cancer Institute; and Emory Healthcare, the largest, most comprehensive health system in Georgia. The Woodruff Health Sciences Center has a $2.3 billion budget, 17,000 employees, 2,300 full-time and 1,900 affiliated faculty, 4,300 students and trainees, and a $4.9 billion economic impact on metro Atlanta.

Source:
Sarah Goodwin
Emory University