Marijuana Damages DNA And May Cause Cancer

Main Category: Alcohol / Addiction / Illegal Drugs
Also Included In: Cancer / Oncology;  Genetics
Article Date: 17 Jun 2009 - 1:00 PDT

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Using a highly sensitive new test, scientists in Europe are reporting "convincing evidence" that marijuana smoke damages the genetic material DNA in ways that could increase the risk of cancer. Their study can be found in the June 15 issue of ACS' Chemical Research in Toxicology, a monthly journal.

Rajinder Singh and colleagues note that toxic substances in tobacco smoke can damage DNA and increase the risk of lung and other cancers. However, there has been uncertainty over whether marijuana smoke has the same effect. Scientists are especially concerned about the toxicity of acetaldehyde, present in both tobacco and marijuana. However, it has been difficult to measure DNA damage from acetaldehyde with conventional tests.

The scientists describe development and use of a modified mass spectrometry method that showed clear indications that marijuana smoke damages DNA. "In conclusion, these results provide evidence for the DNA damaging potential of cannabis [marijuana] smoke, implying that the consumption of cannabis cigarettes may be detrimental to human health with the possibility to initiate cancer development," the article states. "The data obtained from this study suggesting the DNA damaging potential of cannabis smoke highlight the need for stringent regulation of the consumption of cannabis cigarettes, thus limiting the development of adverse health effects such as cancer."

Journal: Chemical Research in Toxicology
"Evaluation of the DNA Damaging Potential of Cannabis Cigarette Smoke by the Determination of Acetaldehyde Derived N2-Ethyl-2´-deoxyguanosine Adducts"

FULL TEXT ARTICLE.

CONTACT:
Rajinder Singh, Ph.D.
University of Leicester
Leicester, U.K.

Source:
Michael Woods
American Chemical Society