The Use Of Short Tandem Repeat Profiling To Characterize Human Bladder Cancer Cell Lines

Main Category: Cancer / Oncology
Article Date: 22 Jun 2009 - 0:00 PDT

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UroToday.com - My laboratory established a series of urothelial cancer cell lines at the University of Michigan. Having worked with them for more than 2 decades, I became aware of some inconsistencies in results. This led to defining the genomic signature of the cell lines to assure that contamination was not the source of these errors. We did find evidence for contamination both in our lab and in the laboratories of our collaborators. Cell line verification has recently been identified by the NIH as a component of high quality research. This manuscript describes unique signatures that can be used to identify my cell lines.

I have made my cell lines available to the academic research community through two well-known resources. The UM-UC-3 cell line has long been available from the American Type Culture Collection (www.atcc.org). The remainder of my UM series of urothelial cancer cell lines are available from the European Collection of Cell Cultures. (www.hpacultures.org.uk/collections/ecacc.jsp)

Commercial entities interested in these cell lines should contact the University of Michigan Office of Technology Transfer.

Written by H. Barton Grossman, MD as part of Beyond the Abstract on UroToday.com

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