Songstress Amy Winehouse died this weekend and joins a long line of musical artists that have abused substances for reasons unknown. Although here official autopsy is not complete, the world is wondering what happened and if her history of drug abuse was to blame. What really is substance abuse and what are the cause and effects?

Drug misuse is a term used commonly for prescription medications with clinical efficacy but abuse potential and known adverse effects linked to improper use, such as psychiatric medications with sedative, anxiolytic, analgesic, or stimulant properties.

Prescription misuse has been variably and inconsistently defined based on drug prescription status, the uses that occur without a prescription, intentional use to achieve intoxicating effects, route of administration, co-ingestion with alcohol, and the presence or absence of abuse or dependence symptoms.

Tolerance relates to the pharmacological property of substances in which chronic use leads to a change in the central nervous system, meaning that more of the substance is needed in order to produce desired effects. Stopping or reducing the use of this substance would cause withdrawal symptoms to occur.

Winehouse’s death follows a lifetime of substance abuse. Though she sought treatment for her drug and alcohol addiction numerous times, it appears that those closest to her could not save her.

Ian Drew, senior music editor at Us Weekly commented to the press about her relationships including the strained association with her ex-husband Blake Fielder Civil:

“Blake was the big reason she got addicted to drugs, according to those close to her. Of course, Blake’s family blames Amy. It was, regardless, a very co-dependent relationship. They fed off each other.”

Depending on the actual compound, drug abuse including alcohol may lead to health problems, social problems, morbidity, injuries, unprotected sex, violence, deaths, motor vehicle accidents, homicides, suicides, physical dependence or psychological addiction.

There is a high rate of suicide in alcoholics and other drug abusers. The reasons believed to cause the increased risk of suicide include the long-term abuse of alcohol and other drugs causing physiological distortion of brain chemistry as well as the social isolation. Another factor is the acute intoxicating effects of the drugs may make suicide more likely to occur. Suicide is also very common in adolescent alcohol abusers, with 1 in 4 suicides in adolescents being related to alcohol abuse.

In the United States approximately 30% of suicides are related to alcohol abuse. Alcohol abuse is also associated with increased risks of committing criminal offences including child abuse, domestic violence, rapes, burglaries and assaults.

Drug abuse, including alcohol and prescription drugs can induce symptomatology which resembles mental illness. This can occur both in the intoxicated state and also during the withdrawal state. In some cases these substance induced psychiatric disorders can persist long after detoxification, such as prolonged psychosis or depression after amphetamine or cocaine abuse. A protracted withdrawal syndrome can also occur with symptoms persisting for months after cessation of use. Benzodiazepines are the most notable drug for inducing prolonged withdrawal effects with symptoms sometimes persisting for years after cessation of use.

Abuse of hallucinogens can trigger delusional and other psychotic phenomena long after cessation of use and cannabis may trigger panic attacks during intoxication and with use it may cause a state similar to dysthymia. Severe anxiety and depression are commonly induced by sustained alcohol abuse which in most cases abates with prolonged abstinence. Even moderate alcohol sustained use may increase anxiety and depression levels in some individuals. In most cases these drug induced psychiatric disorders fade away with prolonged abstinence.

According to press coverage Winehouse’s mother Janis saw this day approaching ahead of time:

“Janis believed her daughter’s death had been only a matter of time when they met just 24 hours earlier. She (Amy) seemed out of it. ‘ Her passing so suddenly still hasn’t hit me.'”

Sources: The Lancet Journal, The Substance Abuse & Mental Health Services Administration and Us Weekly Magazine

Written by Sy Kraft