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"Thienopyridines (antiplatelet agents) are among the most widely prescribed medications, but their use can be complicated by the unanticipated need for surgery. Despite increased risk of thrombosis, guidelines recommend discontinuing thienopyridines 5 to 7 days prior to surgery to minimize bleeding."
"In this trial, cangrelor achieved and maintained target levels of platelet inhibition known to be associated with a low risk of thrombotic events compared with placebo, without a significant excess in bleeding complications. Our data support the hypothesis that intravenous cangrelor is a feasible management strategy in patients waiting for cardiac surgery who require prolonged platelet P2Y12 inhibition after thienopyridine discontinuation."
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Rattue, Grace. "Drug Helps Maintain Platelet Inhibition And Anti-Clotting Levels Prior To Cardiac Surgery." Medical News Today. MediLexicon, Intl., 18 Jan. 2012. Web.
10 Dec. 2013. <http://www.medicalnewstoday.com/articles/240485>
Rattue, G. (2012, January 18). "Drug Helps Maintain Platelet Inhibition And Anti-Clotting Levels Prior To Cardiac Surgery." Medical News Today. Retrieved from
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