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"We report a direct association between cognitive activity and [ 11 C]PiB uptake, suggesting that lifestyle factors found in individuals with high cognitive engagement may prevent or slow deposition of β-amyloid, perhaps influencing the onset and progression of AD."
"It is unlikely that our results reflect a single unitary cause of AD, which is a complex disease with many potential pathogenetic processes. Furthermore, cognitive activity is just one component of a complex set of lifestyle practices linked to AD risk that may be examined in future work. However, the present findings extend previous findings that link cognitive stimulation and AD risk (an indirect downstream effect of Aβ) by providing evidence that is consistent with a model in which cognitive stimulation is linked directly to the AD-related pathology itself."
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Arch Neurol. Published online January 23, 2012. doi:10.1001/archneurol.2011.2748.
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