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"Selective reporting of research results undermines the integrity of the evidence base, which ultimately deprives clinicians of accurate data for prescribing decisions."
"The magnitude of publication bias found for anti-psychotics was less than that found previously for antidepressants, possibly because anti-psychotics demonstrate superiority to placebo more consistently.
With further studies investigating publication bias in other drug classes, a more accurate evidence base can emerge. To that end, increased access to FDA reviews has been advocated. At the present time, the FDA is not as transparent with its clinical trial data as it could be.
It is encouraging that the FDA has convened a Transparency Task Force. If the agency fulfills its mission to increase transparency, the public health will surely benefit."
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“Publication Bias in Antipsychotic Trials: An Analysis of Efficacy Comparing the Published Literature to the US Food and Drug Administration Database” Turner EH, Knoepflmacher D, Shapley L (2012)
PLoS Med 9(3): e1001189. doi:10.1371/journal.pmed.1001189
Visit our Schizophrenia category page for the latest news on this subject.
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6 Dec. 2013. <http://www.medicalnewstoday.com/articles/243196>
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