Sexual dysfunction may be a marker of cardiovascular disease in men with longstanding type 1 diabetes, investigators announced at the 72nd Scientific Sessions of the American Diabetes Association (ADA).

Sara Turek, MPH, and colleagues examined the association of sexual dysfunction with clinical markers of vascular disease in 301 men from the ongoing 50-Year Medalist Study who have had type 1 diabetes for more than 50 years. Turek is a coordinator for the study, which is being conducted at the Joslin Diabetes Center in Boston.

In prior analyses, only about half of the Medalist population has been shown to develop diabetic nephropathy, retinopathy, and neuropathy, which are complications that occur in nearly all type 1 diabetic patients in the general population by about 30 years after their initial diagnosis. The rate of cardiovascular disease in Medalists, however, is similar to that reported in age-matched patients with type 2 diabetes.

Research has also demonstrated that participants in the Medalist Study have usually maintained good long-term glycemic control.

One issue that had not been addressed in the Medalist cohort was sexual dysfunction. “We have noticed that while sexual dysfunction is a common complaint among male Medalists that significantly impairs their quality of life, there is a paucity of data on sexual dysfunction in men with long-duration type 1 diabetes,” Turek commented.

Overall, 210 male Medalists, or 69.8%, had sexual dysfunction as determined by an affirmative response to the question: “Have you ever had sexual problems?”

Males reporting a positive response had a hemoglobin (Hb)A1c of 7.1± 0.9% versus 6.8 ±0.8% in the no-dysfunction cohort (P=0.02). Body mass index (BMI) was 26.1 ±3.8 kg/m2 and. 25.8 ±3.6 kg/m2 (P=0.03) in the two groups, respectively, total cholesterol was 159.3 ±32.1 and 150.1 ±30.6 mg/dL(P=0.02), and high-density lipoprotein (HDL) was 55.1 ±16.2 and 62.1 ±17.8 mg/dL (P

Stephanie Hastings, BA, also a coordinator for the Medalist Study, emphasized that while the determination of erectile dysfunction based on a single question is a limitation to the study, she is confident that the measure provided an accurate assessment of the presence of erectile dysfunction in this group. “Sure, it’s subjective and open to interpretation but we spend a lot of time with our patients, and we find that they are very willing to share whatever information we request in order to help us in our research. We plan to follow up with a lengthier questionnaire, which we expect the majority of the participants to complete openly and honestly,” she said.

Written by: By Jill Stein
Jill Stein is a Paris-based freelance medical writer.