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"Treatment with beta-blockers remains the standard of care for patients with coronary artery disease, especially when they have had a myocardial infarction [MI; heart attack]. The evidence is derived from relatively old post-MI studies, most of which antedate modern reperfusion or medical therapy, and from heart failure trials, but has been widely extrapolated to patients with CAD and even to patients at high risk for but without established CAD.
It is not known if these extrapolations are justified. Moreover, the long-term efficacy of these agents in patients treated with contemporary medical therapies is not known, even in patients with prior MI."
"We have shown in our study that if you have a heart attack and take beta-blockers for a year, you probably will benefit. But the question is, how long after a heart attack would beta-blockers offer a benefit? The European Union says use these drugs long-term only in patients with heart failure. American guidelines say to keep taking them for at least three years after a heart attack."
"Among patients enrolled in the international REACH registry, beta-blocker use was not associated with a lower event rate of cardiovascular events at 44-month follow-up, even among patients with prior history of MI. Further research is warranted to identify subgroups that benefit from beta-blocker therapy and the optimal duration of beta-blocker therapy."
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Not to be reproduced without the permission of Medical News Today.
"Î˛-Blocker Use and Clinical Outcomes in Stable Outpatients With and Without Coronary Artery Disease"
Sripal Bangalore, MD, MHA; Ph. Gabriel Steg, MD; Prakash Deedwania, MD; Kevin Crowley, MS; Kim A. Eagle, MD; Shinya Goto, MD, PhD; E. Magnus Ohman, MD; Christopher P. Cannon, MD; Sidney C. Smith, MD; Uwe Zeymer, MD; Elaine B. Hoffman, PhD; Franz H. Messerli, MD; Deepak L. Bhatt, MD, MPH
JAMA. 2012;308(13):1340-1349. doi:10.1001/jama.2012.1255
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