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"For patients with cancer, the transition from locally controlled disease to a disseminated stage and metastases is probably the most critical threshold, because that transition makes surgical intervention considerably less likely to succeed. We looked at gene copy number changes during the transition from DCIS to IDC and, if so, what patterns of genetic imbalances drive this process."
"DCIS and IDCs are genetically related lesions as they both have similar imbalance patterns. However, according to their aberration patterns, the DCIS lesions are far further advanced than other precursor lesions with more stable genomes, such as colorectal polyps or cervical dysplasias. The considerable degree of intercellular heterogeneity in the DCIS convincingly attests to the fact that chromosomal instability precedes the transition to invasive disease."
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"Single-Cell Genetic Analysis of Ductal Carcinoma in Situ and Invasive Breast Cancer Reveals Enormous Tumor Heterogeneity yet Conserved Genomic Imbalances and Gain of MYC during Progression"
Kerstin Heselmeyer-Haddad, Lissa Y. Berroa Garcia, Amanda Bradley, Clarymar Ortiz-Melendez, Woei-Jyh Lee, Rebecca Christensen, Sheila A. Prindiville, Kathleen A. Calzone, Peter W. Soballe, Yue Hu, Salim A. Chowdhury, Russell Schwartz, Alejandro A. Schäffer, Thomas Ried
The American Journal of Pathology, October 2012, doi 10.1016/j.ajpath.2012.07.012
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23 Apr. 2014. <http://www.medicalnewstoday.com/articles/251575>
Fitzgerald, K. (2012, October 17). "New Insight Into The Progression And Invasiveness Of The Most Common Type Of Breast Cancer." Medical News Today. Retrieved from
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