Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
"For patients with cancer, the transition from locally controlled disease to a disseminated stage and metastases is probably the most critical threshold, because that transition makes surgical intervention considerably less likely to succeed. We looked at gene copy number changes during the transition from DCIS to IDC and, if so, what patterns of genetic imbalances drive this process."
"DCIS and IDCs are genetically related lesions as they both have similar imbalance patterns. However, according to their aberration patterns, the DCIS lesions are far further advanced than other precursor lesions with more stable genomes, such as colorectal polyps or cervical dysplasias. The considerable degree of intercellular heterogeneity in the DCIS convincingly attests to the fact that chromosomal instability precedes the transition to invasive disease."
Copyright: Medical News Today
Not to be reproduced without the permission of Medical News Today.
"Single-Cell Genetic Analysis of Ductal Carcinoma in Situ and Invasive Breast Cancer Reveals Enormous Tumor Heterogeneity yet Conserved Genomic Imbalances and Gain of MYC during Progression"
Kerstin Heselmeyer-Haddad, Lissa Y. Berroa Garcia, Amanda Bradley, Clarymar Ortiz-Melendez, Woei-Jyh Lee, Rebecca Christensen, Sheila A. Prindiville, Kathleen A. Calzone, Peter W. Soballe, Yue Hu, Salim A. Chowdhury, Russell Schwartz, Alejandro A. Schäffer, Thomas Ried
The American Journal of Pathology, October 2012, doi 10.1016/j.ajpath.2012.07.012
Visit our Breast Cancer category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Fitzgerald, Kelly. "New Insight Into The Progression And Invasiveness Of The Most Common Type Of Breast Cancer." Medical News Today. MediLexicon, Intl., 17 Oct. 2012. Web.
12 Dec. 2013. <http://www.medicalnewstoday.com/articles/251575>
Fitzgerald, K. (2012, October 17). "New Insight Into The Progression And Invasiveness Of The Most Common Type Of Breast Cancer." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact the our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/articles/251575.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2013 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.