Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
"In this study, we did something no one else had done before. Using an animal model, we looked at a mutation known to cause intellectual disability and showed for the first time a causative link between abnormal synapse maturation during brain development and life-long cognitive disruptions commonly seen in adults with a neurodevelopmental disorder.
There are a few genes that can't be altered without affecting normal cognitive abilities. SynGAP1 is one of the most important genes in cognition - so far, every time a mutation that disrupts the function of SynGAP1 has been found, that individual's brain simply could not develop correctly. It regulates the development of synaptic function like no other gene I've seen."
"You might think this accelerated development of brain circuits would make you smarter. But the increased excitability actually disorganizes brain development. We think that early maturation of these excitatory synapses disrupts the timing of later developmental milestones. It rains down chaos on this complex process, preventing normal intellectual and behavioral development."
Copyright: Medical News Today
Not to be reproduced without the permission of Medical News Today.
"Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses"
Prof. Gavin Rumbaugh et al
Cell, Volume 151, Issue 4, 709-723, 9 November 2012. 10.1016/j.cell.2012.08.045
Visit our Autism category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Nordqvist, Christian. "Single Protein Affects Intellectual And Behavioral Development." Medical News Today. MediLexicon, Intl., 12 Nov. 2012. Web.
10 Mar. 2014. <http://www.medicalnewstoday.com/articles/252668>
Nordqvist, C. (2012, November 12). "Single Protein Affects Intellectual And Behavioral Development." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/articles/252668.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.