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"This would be a win-win situation for diabetics - they would have more insulin-producing beta cells and there would be fewer glucagon-producing alpha cells."
"We treated human islet cells with a chemical that inhibits a protein that puts methyl chemical groups on histones, which - among many other effects - leads to removal of some histone modifications that affect gene expression.
We then found a high frequency of alpha cells that expressed beta-cell markers, and even produced some insulin, after drug treatment."
"Thus, mammalian pancreatic islet cells display cell-type - specific epigenomic plasticity, suggesting that epigenomic manipulation could provide a path to cell reprogramming and novel cell replacement-based therapies for diabetes."
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"Epigenomic plasticity enables human pancreatic α to β cell reprogramming"
Nuria C. Bramswig, Logan J. Everett, Jonathan Schug, Craig Dorrell, Chengyang Liu, Yanping Luo, Philip R. Streeter, Ali Naji, Markus Grompe and Klaus H. Kaestner
J Clin Invest. Feb 2013. doi:10.1172/JCI66514.
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7 Dec. 2013. <http://www.medicalnewstoday.com/articles/256820>
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