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"We have discovered highly structured EEG patterns that indicate when people are sedated during administration of propofol, when they are unconscious and when they are able to regain consciousness.
These findings provide precise, neurophysiologically principled markers that can be used to monitor the state of a patient's unconsciousness under propofol general anesthesia."
"The consequences of this could be huge, because it would mean we have found a brain state where we know patients will be unconscious and could monitor that brain state in the operating room using EEG.
Appearance of the trough-max pattern would provide a way to predict when patients might be regaining consciousness. With these fundamental neurophysiological markers of the sedative and unconscious states under propofol and with some existing EEG equipment, we can start monitoring these EEG signatures when administering propofol immediately."
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"Electroencephalogram signatures of loss and recovery of consciousness from propofol"
Patrick L. Purdon, Eric T. Pierce, Eran A. Mukamel, Michael J. Prerau, John L. Walsh, Kin Foon K. Wong, Andres F. Salazar-Gomez, Priscilla G. Harrell, Aaron L. Sampson, Aylin Cimenser, ShiNung Ching, Nancy J. Kopell, Casie Tavares-Stoeckel, Kathleen Habeeb, Rebecca Merhar, and Emery N. Brown
PNAS Early Edition
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8 Mar. 2014. <http://www.medicalnewstoday.com/articles/257313>
Nordqvist, J. (2013, March 7). "When Patients On General Anesthetic Are Conscious - EEG Patterns Can Tell." Medical News Today. Retrieved from
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