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"There is an increasing appreciation that animal studies do not always predict findings in humans. The nPOD program is therefore a very precious resource."
"These findings lend additional weight to concerns regarding the effects of long term GLP-1-related therapy, with respect to both unintended proliferative actions on the exocrine pancreas and now also a possible increased risk of neuroendocrine tumors. In addition to the surveillance previously recommended for the potential association of GLP-1- based therapy and pancreatic cancer risk, the current data imply that surveillance for a possible increased risk of pancreatic neuroendocrine tumors is warranted."
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”Marked Expansion of Exocrine and Endocrine Pancreas with Incretin Therapy in Humans with increased Exocrine Pancreas Dysplasia and the potential for Glucagon-producing Neuroendocrine Tumors”
Diabetes March 2013. Doi: 10.2337/db12-1686
Alexandra E Butler, Martha Campbell-Thompson, Tatyana Gurlo, David W Dawson, Mark Atkinson and Peter C Butler
Visit our Diabetes category page for the latest news on this subject.
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