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"Previous studies have shown that our bodies are already equipped to block viruses such as Ebola, influenza, West Nile, and SARS. The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry."
"The membrane is usually very flexible. With an increase in cholesterol it becomes rigid, and doesn't allow viruses to pass through the endosome compartment into cytosol, the fluid portion inside cells. We were surprised to find that changing the balance of cholesterol concentration affects viral entry."
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"The Antiviral Effector IFITM3 Disrupts Intracellular Cholesterol Homeostasis to Block Viral Entry"
Samad Amini-Bavil-Olyaee, Youn Jung Choi, Jun Han Lee, Mude Shi, I-Chueh Huang, Michael Farzan, Jae U. Jung
Cell Host & Microbe. Volume 13, Issue 4, 452-464, 17 April 2013. 10.1016/j.chom.2013.03.006
Visit our Infectious Diseases / Bacteria / Viruses category page for the latest news on this subject.
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