Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
Researchers in Canada found that switching off a gene in the cancer stem cells that drive colon cancer stops them from being able to renew themselves. They say their study offers a starting point to treatments that could shut the cancer down.
Principal investigator John Dick, a senior scientist at the Princess Margaret Cancer Centre, University Health Network, Toronto, pioneered the study of cancer stem cells by identifying leukemia stem cells in 1994. He is also a Professor in the Department of Molecular Genetics, University of Toronto.
Just over a decade later, in 2007, Prof. Dick identified colon cancer stem cells. He is also known for pioneering work that isolated a pure human blood stem cell capable of regenerating the entire blood system.
He and his colleagues write about their latest discovery in a recent online issue of Nature Medicine.
Prof. Dick, who also holds a Canada Research Chair in Stem Cell Biology, says:
"This is the first step toward clinically applying the principles of cancer stem cell biology to control cancer growth and advance the development of durable cures."
He talks about their latest research in the video below.
Senior co-author and surgeon-scientist Dr. Catherine O'Brien, also of the Princess Margaret
Cancer Centre and the University of Toronto, adds:
"The clinical potential of this research is exciting because it maps a viable way to develop
targeted treatment for colon cancer patients."
"The clinical potential of this research is exciting because it maps a viable way to develop targeted treatment for colon cancer patients."
Colorectal cancer is the third leading cause of cancer deaths in the developed world.
For their study, the team ran a series of pre-clincal experiments where they replicated human colon cancer in mice to find out more about targeting the cancer stem cells.
They found that the gene BMI-1 - which has already been found to play a role in maintaining stem cells in other cancers - also drives self-renewal, proliferation and survival in colon cancer stem cells.
They then showed they could block the gene with a small molecule inhibitor, indicating it may be possible to develop drugs that stop colon cancer in its tracks, as Prof. Dick explains:
"When we blocked the BMI-1 pathway, the stem cells were unable to self-renew, which resulted in long-term and irreversible impairment of tumor growth. In other words, the cancer was permanently shut down."
Dr. O'Brien says it has already been shown that about 65% of colon cancer patients have the BMI-1 biomarker, adding:
"With the target identified, and a proven way to tackle it, this knowledge could readily translate into first-in-human trials to provide more personalized cancer medicine."
Written by Catharine Paddock PhD
Copyright: Medical News Today
Not to be reproduced without the permission of Medical News Today.
Self-renewal as a therapeutic target in human colorectal cancer; Antonija Kreso, Peter van Galen, Nicholas M Pedley, Evelyne Lima-Fernandes, Catherine Frelin, and others; Nature Medicine, Published 1 December 2013; DOI:10.1038/nm.3418; Abstract.
Additional source: University Health Network press release via EurekAlert 1 December 2013.
Visit our Colorectal Cancer category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Paddock, Catharine. "New colorectal cancer target found in stem cell gene." Medical News Today. MediLexicon, Intl., 2 Dec. 2013. Web.
24 Apr. 2014. <http://www.medicalnewstoday.com/articles/269539>
Paddock, C. (2013, December 2). "New colorectal cancer target found in stem cell gene." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/articles/269539.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT is the registered trade mark of MediLexicon International Limited.