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Scientists from the University of Queensland in Australia say they have discovered that a gene called mec-17 has the ability to protect against adult-onset progressive nerve degeneration. This is according to a study published in the journal Cell Reports.
The research team, led by Dr. Brent Neumann of the Queensland Brain Institute (QBI) at the University of Queensland, say their discovery may one day lead to a cure for a number of neurodegenerative diseases, such as motor neuron disease, Parkinson's disease, Huntington's disease and Alzheimer's disease.
To reach their findings, the investigators analyzed a small roundworm called Caenorhabditis elegans. They note that the roundworm is a genetic model commonly used to better understand neurobiology at a basic level.
From this, they discovered that mec-17 - a gene found among many species - protects axons, also known as nerve fibers. These are parts of the nerve cells, or neurons, that are responsible for conducting impulses between the cells.
The gene protects the axon by sustaining its cytoskeletal structure, say the investigators. This is made of proteins that maintain a nerve cell's shape, support and movement.
Protection of the cytoskeletal structure allows appropriate transportation of important molecules and organelles, such as mitochondria, through the axon.
The researchers say their findings show that the axon plays a crucial part in the health of the nerve cells and should be a focus for future research.
"This study demonstrates that mec-17 normally functions to protect the nervous system from damage," says Dr. Neumann.
"This knowledge can now be used to understand precisely how the gene achieves this and to discover other molecules that are used by the nervous system for similar protective functions."
He adds that future research will involve "bypassing" the function of mec-17 and the analysis of other genes that may protect the nervous system from damage.
Dr. Massimo Hilliard, also of the QBI and study author, says their findings could lead to a better understanding of the mechanisms of neuronal injury and neurodegenerative diseases that are "characterized by axonal pathology."
"This is an important step to fully understand how axonal degeneration occurs, and thus facilitates development of therapies to prevent or halt this damaging biological event.
It's our hope that this could one day lead to more effective treatments for patients suffering from conditions causing neuronal degeneration."
Medical News Today recently reported on a study suggesting that concussion may be a cause of plaque build-up in the brain that is linked to Alzheimer's disease.
Written by Honor Whiteman
Copyright: Medical News Today
Not to be reproduced without the permission of Medical News Today.
Loss of MEC-17 Leads to Microtubule Instability and Axonal Degeneration, doi: 10.1016/j.celrep.2013.12.004, Brent Neumann, Massimo A. Hilliard, published in Cell Reports, 26 December 2013. Abstract
Research into axon degeneration hits a nerve, news release from the University of Queensland, accessed 20 December 2013.
Visit our Neurology / Neuroscience category page for the latest news on this subject.
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