The grapefruit was bred in the 18th century as a cross between a pomelo and an orange. They were given the name grapefruit because of the way they grew in clusters similar to grapes. Grapefruits vary in hue from white or yellow to pink and red and can range in taste very acidic and even bitter or sweet and sugary.
Grapefruits are low in calories but full of nutrients. They support clear, healthy skin, help to lower our risk for many diseases and conditions and may even help with weight loss as part of an overall healthy and varied diet.
This MNT Knowledge Center feature is part of a collection of articles on the health benefits of popular foods.
Contents of this article:
You will also see introductions at the end of some sections to any recent developments that have been covered by MNT's news stories. Also look out for links to information about related conditions.
Nutritional breakdown of grapefruit
Grapefruits vary in hue from white or yellow to pink and red and can range in taste very acidic and even bitter or sweet and sugary.
According to the USDA National Nutrient Database, half of a medium pink grapefruit, (3 ¾ in diameter) contains approximately 52 calories, 0 grams of fat, 0 grams of sodium, 0 grams of cholesterol, 13 grams of carbohydrate (including 8.5 grams of sugar and 2 grams of dietary fiber), and 1 gram of protein.
Grapefruits also contain small amounts of vitamin E, thiamin, riboflavin, niacin, folate, pantothenic acid, potassium, phosphorus, manganese, zinc and copper.
Not only are pink grapefruits high in common vitamins and minerals, they also pack a powerful antioxidant punch with lycopene and beta-carotene along with the phytonutrients limonoids and naringenin.
Studies have shown that fresh pink or red grapefruit contains higher quantities of bioactive compounds and has significantly higher antioxidant potential than white or yellow grapefruit.
Possible health benefits of consuming grapefruit
Consuming fruits and vegetables of all kinds has long been associated with a reduced risk of many adverse health conditions. Many studies have suggested that increasing consumption of plant foods like grapefruit decreases the risk of obesity, diabetes, heart disease and overall mortality while promoting a healthy complexion, increased energy, and overall lower weight.
Grapefruit may not be a miracle weight loss food as touted in some previously popular fad diets, but consuming grapefruit as part of a healthy diet may just give you a little boost. The Scripps Clinic 'Grapefruit Diet' study, led by Dr. Ken Fujioka, monitored the weight and metabolic factors of 91 obese men and women for 12 weeks. Each participant was randomly assigned to one of four groups to receive either placebo capsules along with 7 ounces of apple juice, grapefruit capsules with 7 ounces of apple juice, 8 ounces of grapefruit juice with a placebo capsule or half of a fresh grapefruit with a placebo capsule three times a day before each meal.
After 12 weeks, the fresh grapefruit group had lost the most weight at 3.52 lbs, the grapefruit juice group had lost 3.3 lbs, the grapefruit capsule group had lost 2.42 lbs, and the placebo group had lost 0.66 lbs. According to the researchers, there was also a significant reduction in 2-hour post-glucose insulin level in the grapefruit group compared with placebo. Half of a fresh grapefruit eaten before meals was also associated with improved insulin resistance.
According to the American Heart Association, eating higher amounts of a compound found in citrus fruits like oranges and grapefruit may lower ischemic stroke risk for women. Those who ate the highest amounts of citrus had a 19 percent lower risk of ischemic stroke than women who consumed the least.5
Blood pressure and heart health
The powerful nutrient combination of fiber, potassium, lycopene, vitamin C and choline in grapefruit all help to maintain a healthy heart.
One study found that a diet supplemented with fresh red grapefruit positively influences blood lipid levels, especially triglycerides. Researchers concluded that the addition of fresh red grapefruit to the diet could be beneficial for people with atherosclerosis wanting to lower their high lipid levels, especially triglycerides.
In one study, those who consumed 4069 mg of potassium per day had a 49% lower risk of death from ischemic heart disease compared with those who consumed less potassium (about 1000 mg per day).3
High potassium intakes are also associated with a reduced risk of stroke, protection against loss of muscle mass, preservation of bone mineral density and reduction in the formation of kidney stones.3
Increasing potassium intake is also important for lowering blood pressure because of its powerful vasodilation effects.
As an excellent source of the strong antioxidant vitamin C as well as other antioxidants, grapefruit can help combat the formation of free radicals known to cause cancer. Lycopene intake has been linked with a decreased risk of prostate cancer prevention in several studies and foods high in vitamin C and beta-carotene have been shown to lower the risk of esophageal cancer in particular.
Digestion and regularity
Grapefruit, because of its water and fiber content, helps to prevent constipation and promote regularity for a healthy digestive tract.
As one of the most hydrating fruits in the world made up of 91% water (just below watermelon) and full of important electrolytes, grapefruit is a great snack to have on hand to prevent dehydration.
The antioxidant vitamin C, when eaten in its natural form (in fresh produce as opposed to supplement form) or applied topically, can help to fight skin damage caused by the sun and pollution, reduce wrinkles and improve overall skin texture. Vitamin C plays a vital role in the formation of collagen, the main support system of skin. Hydration and vitamin A are also crucial for healthy looking skin, both of which grapefruits can provide.
The risks for developing asthma are lower in people who consume a high amount of certain nutrients. One of these nutrients is vitamin C, found in many fruits and vegetables including grapefruit.
How to incorporate more grapefruit into your diet
Grapefruits should be picked at their peak of ripeness because they do not ripen or improve in quality after being picked, unlike some other fruits. Grapefruits should be stored at room temperature, away from direct sunlight. Choose a grapefruit that is heavy for its size and has a little spring when squeezed.
While it's sometimes hard to find good quality fruits and vegetables in the winter, it is the perfect time to buy citrus. Winter is the peak season for grapefruit, oranges and other citrus fruits.
Add some grapefruit slices to your salad at lunch or dinner.
- Keep a bowl on the kitchen table or counter stocked with fresh fruit from the season. Seeing the fruits readily available will likely cause you to choose them as a snack more often than raiding the cupboards for a less healthy snack
- Make a fruit salad with strawberries, pineapple, sliced grapefruit, mandarin oranges and grapes
- Add some grapefruit slices to your salad at lunch or dinner. Compliment the oranges with walnuts or pecans, crumbled cheese and a light balsamic or citrus vinaigrette dressing
- Make your own juice! Nothing tastes better than freshly squeezed fruit juice in the morning. When you make your own, you can be sure there are no added preservatives or sweeteners.
Check out some of these healthy recipes at home to help incorporate more grapefruit into your diet:Pear-fect Grapefruit Smoothie
Grapefruit Yogurt Cake
Salmon Kebabs with Grapefruit and Quinoa Salad
Potential health risks of consuming grapefruit
Grapefruit intake should be avoided when taking certain medications, because of its enzyme binding ability. This means the medication can pass from your gut to your bloodstream easier and faster than normal. In many cases, these higher levels can be dangerous. Statin drugs, calcium channel blockers and psychiatric drugs are some of the most-common medications that interact with grapefruit.
For a list of specific medication-interactions with grapefruit, please see the table provided by The Harvard Medical School Family Health Guide.1
Also take caution when consuming grapefruit if you have a current kidney condition. Too much potassium can be harmful to those whose kidneys are not fully functional. If your kidneys are unable to remove excess potassium from the blood, it could be fatal.
Those with gastro-esophageal reflux disease (GERD) may experience an increase in symptoms such as heartburn and regurgitation when consuming highly acidic foods such as citrus fruit, however individual reactions vary.
Keep in mind that is the total diet or overall eating pattern that is most important in disease prevention and achieving good health. It is better to eat a diet with a variety than to concentrate on individual foods as the key to good health.
Recent developments on grapefruit from MNT news
Scientists at Royal Holloway, University of London, have discovered that a natural product found in grapefruit can prevent kidney cysts from forming.
University of Louisville researchers have uncovered how to create nanoparticles using natural lipids derived from grapefruit, and have discovered how to use them as drug delivery vehicles. UofL scientists Huang-Ge Zhang, D.V.M., Ph.D., Qilong Wang, Ph.D., and their team have published their findings in Nature Communications.
It is common knowledge that a diet high in fat can lead to weight gain. But could drinking grapefruit juice reduce this effect? A new study by researchers at the University of California-Berkeley claims it did for mice fed a high-fat diet, and it even lowered blood glucose levels and improved insulin tolerance.
Written by: Megan Ware, RDN, LD, registered dietitian and nutritionist and Helen Yuan, nutrition intern.