Dissolving Heart Stent Created

Featured Article
Main Category: Cardiovascular / Cardiology
Also Included In: Medical Devices / Diagnostics
Article Date: 11 Dec 2006 - 12:00 PDT


Imagine a heart stent which completely dissolves after a while, minimizing the risk of side-effects, such as secondary blood clots, while at the same time making it easier to perform further surgery on the affected artery. Such a stent has been developed at Auckland City Hospital, New Zealand.

A heart stent is a type of scaffold, or mesh, which is placed in a blocked/narrowed artery to keep it open. Stents are commonly used for heart attack patients, people with a clogged artery, as well as patients with angina. Currently, stents are made of metal and stay where they are placed, intact, for life. The problem is that because they are like a mesh, clogs can build up and created blockages - these blockages can occur many years after the stents were placed. These blockages are called 'late stent thrombosis'.

This novel stent, called the BVS everolimus-eluting stent (Bioabsorbable Vascular Solutions, Inc.), is made of a polymer that disappears after three years. The polymer turns into lactic acid. It eventually breaks down into carbon dioxide and water (metabolized through the Krebs cycle).

Dr John Ormiston, team leader, said "You wouldn't want to keep a cast on a broken arm after its mended. In the same way, there is no point keeping a stent in place after the artery has healed. I think we'll look back in 10 years' time and laugh at the idea of putting bits of metal into coronary arteries that stay there for ever."

The researchers say this new stent has many advantages:

-- Lower risk of late stent thrombosis
-- Easier to perform further surgeries on the artery
-- Clearer CT and MRI images because stents are not made of metal
-- As they are flexible, they fit more snugly inside the artery

It is also a drug eluting stent, meaning it releases a drug - its elution period is about 120 days.

The BVS stent had a high success rate in a trial with 30 patients who had single, de novo, native coronary artery lesions. - no major adverse cardiac events were reported during a 30-day follow-up, according to Dr. Ormiston, who works at the Green Lane and Mercy Hospital in Auckland, New Zealand. He said there were no cases of ischemia-driven major adverse cardiac events during the patients' stay in hospital. The procedural success rate was 100%.

"Bioabsorbable Coronary Stents Successfully and Safely Deployed"
Transcatheter Cardiovascular Therapeutics
Click here to view report online

"Auckland patients test meltaway heart device"
Mercy Angiography, New Zealand
Click here to view article online

Written by: Christian Nordqvist
Editor: Medical News Today
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

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