Antihistamine Offers Relief For Cirrhosis Patients With Insomnia - Medication Restores Normal Chemical Function In The Brain, Improving Sleep

Main Category: Sleep / Sleep Disorders / Insomnia
Also Included In: Immune System / Vaccines
Article Date: 26 May 2007 - 1:00 PST

email to a friend   printer friendly   view / write opinions

A common medication used by allergy sufferers may offer relief to cirrhosis patients that suffer from insomnia. A new study in The American Journal of Gastroenterology shows that the antihistamine hydroxyzine is an effective treatment for restoring normal sleep patterns when liver damage causes chemical pathways in the brain to be disrupted.

"In patients with cirrhosis of the liver, histamine levels in the brain can be altered," says study author Dr. Laurent Spahr. "In the brain, histamine regulates the sleep-wake cycle, so if levels of this chemical get out of balance, so do sleep patterns." In this study, 65 percent of the patients receiving hydroxyzine before bedtime experienced improved sleep quality.

Dr. Spahr says that hydroxyzine is a welcome alternative to 'classical' sleeping pills, as they are usually ineffective and can lead to serious side effects in cirrhosis patients, such as coma. Recent practice guidelines forbid the use of these 'classical' drugs for cirrhosis patients, declaring them too dangerous.

According to Dr. Spahr, however, hydroxyzine is not risk-free. "This medication must be used with caution. Patients must be monitored carefully by a physician for their particular response to the drug, and should be taken off the medication if there are any signs of trouble."

The American Journal of Gastroenterology meets the day-to-day demands of clinical practice. Aimed at practicing clinicians, the journal's articles deal directly with the disorders seen most often in patients. The journal brings a broad-based, interdisciplinary approach to the study of gastroenterology, including articles reporting on current observations, research results, methods of treatment, drugs, epidemiology, and other topics relevant to clinical gastroenterology. For more information, please visit http://www.blackwellpublishing.com/ajg.

Blackwell Publishing is the world's leading society publisher, partnering with 665 medical, academic, and professional societies. Blackwell publishes over 800 journals and has over 6,000 books in print. The company employs over 1,000 staff members in offices in the US, UK, Australia, China, Singapore, Denmark, Germany, and Japan and officially merged with John Wiley & Sons, Inc.'s Scientific, Technical, and Medical business in February 2007. Blackwell's mission as an expert publisher is to create long-term partnerships with our clients that enhance learning, disseminate research, and improve the quality of professional practice. For more information on Blackwell Publishing, please visit http://www.blackwellpublishing.com or http://www.blackwell-synergy.com.