Chromosome 'caps' predict bone marrow disease

Main Category: Public Health
Article Date: 19 Apr 2004 - 0:00 PDT

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For the first time, Imperial College London researchers at the Hammersmith Hospital studying a rare bone marrow disease have found an association between 'telomere shortening' - changes in the lengths of DNA repeats at the end of chromosomes - and the time of development and severity of disease symptoms in patients.

Reporting in Nature Genetics today (18 April 2004), the Hammersmith team, collaborating with scientists at the Washington University School of Medicine in the USA, is hoping that the findings could lead to better screening for this and other diseases, as well as suggest targets for new therapies.

Dyskeratosis congenita (DC) is a rare but serious inherited condition where the body is unable to make adequate numbers of blood cells. It can lead to bone marrow failure and a much higher risk of developing cancer. People with DC also have a mutation in an enzyme (telomerase) which repairs telomeres (sections of DNA repeats which 'cap' the ends of chromosomes) and as a result, telomere length in their chromosomes is shorter.

In families with a history of a certain type of the disease, autosomal dominant DC, the disease becomes more severe in succeeding generations. "We found when we looked at the DNA of families that suffer from the disease, the telomere length gave an indication of how soon and how severely patients were likely to get the disease," said Inderjeet Dokal, Professor of Haematology at Imperial College London and one of the authors of the study. "This 'disease anticipation' was only thought to occur in specific neurological diseases until now."

The researchers propose that the shortening of the DNA repeats in telomeres may be responsible for disease anticipation. They investigated the telomere lengths and disease status of 27 affected individuals from eight families with the autosomal dominant sub-type of DC and compared this to telomere length measurements in normal families. "The findings of this study provides a novel mechanism for disease anticipation in humans," explains Professor Dokal.

Notes

The Hammersmith Researchers are Prof Inderjeet Dokal, Dr Tom Vulliamy, Dr Anna Marrone, Dr Richard Szydlo, Dr Amanda Walne and Mr Stevens. The collaborator in the US is Dr Phil Mason, Washington University School of Medicine.

Notes

Telomeres are stretches of repeated DNA sequences that cap the ends of chromosomes - the stores of our genetic information. Telomeres protect genes in the chromosome from damage and prevent chromosomes from fusing to each other. In most cells telomeres shorten with each cell division because the strands of DNA are not fully copied. To compensate, an enzyme called telomerase is produced which 'adds on' stretches of the DNA sequence. Changes in telomere length are implicated in human ageing and cancer, so knowing what regulates telomere length could improve our understanding of these processes.

The paper will be published online from 1800 BST on 18 April 2004 at http://dx.doi.org/10.1038/ng1346


Contact: Tony Stephenson at.stephenson@imperial.ac.uk
44-207-594-6712
Imperial College of Science, Technology and Medicine