New Data Shows Veteran Drug Could Treat Cocaine Dependence

Main Category: Alcohol / Addiction / Illegal Drugs
Article Date: 08 Aug 2007 - 1:00 PDT

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A recent pilot study conducted by the Medical University of South Carolina (MUSC) supports the use of mucus-dissolving agent /N/-acetylcysteine (NAC) for reducing an addict's desire and interest in cocaine by increasing a chemical found in the brain.

Currently, there is no drug approved by the U.S. Food and Drug Administration for the treatment of cocaine dependence. Study results are comparable to existing data and animal models that confirm NAC as a promising option. "Our team is very encouraged by these preliminary positive findings," said Robert Malcolm, M.D., MUSC professor of psychiatry and director of outpatient substance abuse programs. "We now are working on a large outpatient treatment trial with N-acetylcysteine and hope to have more information on effectiveness and safety in a 'real world setting' within 12 to 18 months."

Cocaine-dependent participants were either given the NAC medication or a placebo in the double-blind trial, which lasted during two separate, three-day hospital stays. In addition to medication, participants were shown slides depicting cocaine and its usage. Researchers lead by Steven LaRowe, Ph.D., MUSC research assistant professor of psychiatry, then gathered and recorded psychophysical data during their observations. Those that were given the NAC drug reported less interest and desire in using cocaine while responding to the visual stimulants, and even watched the cocaine slides for a smaller amount of time.

About MUSC

Founded in 1824 in Charleston, The Medical University of South Carolina is the oldest medical school in the South. Today, MUSC continues the tradition of excellence in education, research, and patient care. MUSC educates and trains more than 3,000 students and residents, and has nearly 10,000 employees, including 1,300 faculty members. As the largest non-federal employer in Charleston, the university and its affiliates have collective annual budgets in excess of $1.3 billion. MUSC operates a 600-bed medical center, which includes a nationally recognized Children's Hospital and a leading Institute of Psychiatry. For more information on academic information or clinical services, visit http://www.musc.edu or http://www.muschealth.com.