Search is Powered by Google
Follow us on:
Follow our health news on Twitter
Follow Our News on Facebook
Personalization
login | register
GastroIntestinal / Gastroenterology News

Gastrointestinal Bleeding And Drug Interactions With Warfarin

Main Category: GastroIntestinal / Gastroenterology
Also Included In: Blood / Hematology;  Cardiovascular / Cardiology
Article Date: 15 Aug 2007 - 10:00 PDT

email icon email to a friend   printer icon printer friendly   write icon view / write opinions   rate icon rate article
Current Article Ratings:

Patient / Public:not yet rated

Health Professional:5 stars

5 (1 votes)

Article Opinions: 0 posts

Anticoagulants (e.g., warfarin) and antiplatelet drugs (e.g., acetylsalicylic acid) are key therapeutic agents in the treatment of cardiovascular diseases.

In this study, Joseph Delaney MSc, Dr. James Brophy and colleagues looked for drug-drug interactions in 4,028 cases with a diagnosis of gastrointestinal bleeding and 40,171 matched controls in the United Kingdom. They documented a 4-6-fold increase in the rate of gastrointestinal bleeding associated with the combined use of the anticoagulant warfarin and antiplatelet agents.

This real-world study of prescription data from general practices observed much higher rates of bleeding than those derived from a meta-analysis of randomized clinical trials.

The authors write that physicians should be aware of these risks to better assess their patients' therapeutic risk-benefit profiles.

In a related commentary, David Juurlink PhD explains the main drug interactions with the anticoagulant warfarin.

----------------------------
Article adapted by Medical News Today from original press release.
----------------------------

http://www.cmaj.ca/pressrelease/pg347.pdf

Source: Dr. James Brophy
Canadian Medical Association Journal

View drug information on Warfarin Sodium tablets.



Personalized Homepage Weekly Newsletters Daily News Alerts
Hemophilia Opioid Induced Constipation Pneumococcal Disease ADHD Anxiety Asthma Atrial Fibrillation Autism Cancer Diabetes Lung Cancer Lupus Medicare / Medicaid Obesity and BMI Pancreatic Cancer Stem Cells All 'What Is...' Articles

Ophthalmology Urology
About Us News Licensing Free Website Feeds Free Tools & Content Tell a Friend Accessibility Help / FAQ Article Submission Links Contact Us

add medical news today to your facebook
medical news gadget

Please fill in our survey

Swine Flu Image

Swine Flu Updates

- Latest Swine Flu News
- What is Swine Flu?
- Map Of H1N1 Outbreaks
- Swine Flu - Top 20 FAQ
- Daily Email News Alerts
Stick with Medical News Today for the latest news updates on swine flu.


These are the most read articles from this news category for the last 6 months:
Top Article Star
What Is Anal Cancer? What Causes Anal Cancer?
07 Jul 2009
Anal cancer occurs in the anus, the end of the gastrointestinal tract. Anal cancer is very different from colorectal cancer, which is much more common. Anal cancer's causes, risk factors, clinical progression, staging and...


Talking with Your Doctor image Talking with Your Doctor

Talking with your doctor can sometimes be difficult. Good health care, however, depends on an open dialogue between patients and doctors...

Symptoms of Carcinoid image Symptoms of Carcinoid

Turning red at a party can mean you've had one drink too many. But flushing is sometimes a sign of carcinoid disease. Learn about these slow-growing, often-overlooked cancers...

View more videos...